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Review of clinical applications of radiation-enhancing nanoparticles
- Source :
- Biotechnology Reports, Vol 28, Iss, Pp e00548-(2020), Biotechnology Reports, Biotechnology Reports, 2020, 28, pp.e00548-. ⟨10.1016/j.btre.2020.e00548⟩, Biotechnology Reports, Elsevier, 2020, 28, pp.e00548-. ⟨10.1016/j.btre.2020.e00548⟩
- Publication Year :
- 2020
- Publisher :
- Elsevier, 2020.
-
Abstract
- Highlights • Inorganic nanoparticles activated by radiotherapy (RT) increase dose deposition within cancer cells compared to RT alone. • Recently, clinical evidence of the radiation-enhancing effects of NP has emerged. • Two radio-enhancement NP are currently under investigation in clinical trials: hafnium oxide NP and gadolinium-based NP. • So far, 229 patients have been treated with NP and RT for soft tissue sarcoma, head and neck cancers or liver cancer. • Intratumoral hafnium oxide nanoparticles were safe and improved efficacy in locally advanced sarcoma.<br />Purpose Clinical evidence of the radiation-enhancing effects of nanoparticles has emerged. Materials and methods We searched the literature in English and French on PubMed up to October 2019. The search term was “nanoparticle” AND “radiotherapy”, yielding 1270 results. Results The two main NP used in clinical trials were hafnium oxide and gadolinium involving a total of 229 patients. Hafnium oxide NP were used in three phase 1/2 trials on sarcoma, head and neck squamous cell carcinoma or liver cancer and one phase 2/3 trial. There are six ongoing phase 1/2 clinical trials to evaluate the combination of gadolinium-based NP and RT for the treatment of brain metastases and cervical cancer. Conclusion So far, intratumoral hafnium oxide nanoparticles were safe and improved efficacy in locally advanced sarcoma.
- Subjects :
- 0106 biological sciences
Oncology
medicine.medical_specialty
Gadolinium
medicine.medical_treatment
[SDV]Life Sciences [q-bio]
lcsh:Biotechnology
chemistry.chemical_element
Review Article
01 natural sciences
Applied Microbiology and Biotechnology
03 medical and health sciences
010608 biotechnology
Internal medicine
lcsh:TP248.13-248.65
medicine
030304 developmental biology
Radiothérapie
Cancer
Cervical cancer
0303 health sciences
Radiotherapy
business.industry
Nanoparticules
medicine.disease
Head and neck squamous-cell carcinoma
3. Good health
Clinical trial
Radiation therapy
[SDV] Life Sciences [q-bio]
chemistry
Nanoparticles
Sarcoma
Liver cancer
business
Biotechnology
Subjects
Details
- Language :
- English
- ISSN :
- 2215017X
- Volume :
- 28
- Database :
- OpenAIRE
- Journal :
- Biotechnology Reports
- Accession number :
- edsair.doi.dedup.....311affecd2529f9439b9d2588154e56d