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Aminomethylation of Aryl Bromides by Nickel-Catalyzed Electrochemical Redox Neutral Cross Coupling
- Source :
- Organic letters. 23(24)
- Publication Year :
- 2021
-
Abstract
- We develop an electrochemical nickel-catalyzed aminomethylation of aryl bromides under mild conditions. The convergent paired electrolysis makes full use of anode and cathode processes, free of a terminal oxidant, a sacrificial anode, a metal reductant, and a prefunctionalized radical precursor. In addition, this method exhibits wide functional group tolerance (63 examples), including some sensitive substituents and aromatic heterocycles. This redox neutral cross coupling provides a more environmentally friendly and synthetic practical protocol for forging C(sp
- Subjects :
- Organic Chemistry
Physical and Theoretical Chemistry
Biochemistry
Subjects
Details
- ISSN :
- 15237052
- Volume :
- 23
- Issue :
- 24
- Database :
- OpenAIRE
- Journal :
- Organic letters
- Accession number :
- edsair.doi.dedup.....3117a7e061c713fa8d5dda36806b76e0