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Antecedents and correlates of blood concentrations of neurotrophic growth factors in very preterm newborns
- Publication Year :
- 2017
-
Abstract
- To identify the antecedents and very early correlates of low concentrations of neurotrophic growth factors in the blood of extremely preterm newborns during the first postnatal month.Using an immunobead assay, we measured the concentrations of neurotrophin 4 (NT4), brain-derived neurotrophic factor (BDNF), and basic fibroblast growth factor (bFGF) in blood spots collected on postnatal days 1 (N=1062), 7 (N=1087), 14 (N=989), 21 (N=940) and 28 (N=880) from infants born before the 28th week of gestation. We then sought the correlates of measurements in the top and bottom quartiles for gestational age and day the specimen was collected.The concentrations of 2 neurotrophic proteins, NT4 and BDNF, were low among children delivered for medical (maternal or fetal) indications, and among those who were growth restricted. Children who had top quartile concentrations of NT4, BDNF, and bFGF tended to have elevated concentrations of inflammation-related proteins that day. This pattern persisted for much of the first postnatal month.Delivery for medical indications and fetal growth restriction are associated with a relative paucity of NT4 and BDNF concentrations during the first 24 h after very preterm birth. Elevated blood concentrations of NT4, BDNF, and bFGF tended to co-occur with indicators of systemic inflammation on the same day.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Immunology
Neovascularization, Physiologic
Gestational Age
Fibroblast growth factor
Biochemistry
Article
Fetal Development
03 medical and health sciences
0302 clinical medicine
Fetus
Neurotrophic factors
Internal medicine
medicine
Immunology and Allergy
Humans
Nerve Growth Factors
Prospective Studies
Prospective cohort study
Molecular Biology
Brain-derived neurotrophic factor
Inflammation
biology
business.industry
Brain-Derived Neurotrophic Factor
Infant, Newborn
Gestational age
Hematology
Fibroblast Growth Factors
030104 developmental biology
Endocrinology
Nerve growth factor
Infant, Extremely Premature
biology.protein
Cytokines
Female
business
030217 neurology & neurosurgery
Neurotrophin
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....31103ec7eea182aaf630ca6a53a0ad86