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Avian influenza: genetic evolution under vaccination pressure
- Source :
- Virology Journal, Virology Journal, Vol 5, Iss 1, p 15 (2008)
- Publisher :
- Springer Nature
-
Abstract
- Antigenic drift of avian influenza viruses (AIVs) has been observed in chickens after extended vaccination program, similar to those observed with human influenza viruses. To evaluate the evolutionary properties of endemic AIV under high vaccination pressure (around 2 billion doses used in the last 12 years), we performed a pilot phylogenic analysis of the hemagglutinin (HA) gene of AIVs isolated from 1994 to 2006. This study demonstrates that Mexican low pathogenicity (LP) H5N2-AIVs are constantly undergoing genetic drifts. Recent AIV isolates (2002–2006) show significant molecular drifts when compared with the H5N2 vaccine-strain or other field isolates (1994–2000). This study also demonstrates that molecular drifts in the HA gene lineages follow a yearly trend, suggesting gradually cumulative sequence mutations. These findings might explain the increasing incidence of LP H5N2 AIV isolated from commercial avian farms. These findings support recent concerns about the challenge of AIV antigenic drift and influenza epidemics.
- Subjects :
- Endemic Diseases
animal diseases
Short Report
Hemagglutinin (influenza)
Hemagglutinin Glycoproteins, Influenza Virus
Biology
medicine.disease_cause
Antigenic drift
lcsh:Infectious and parasitic diseases
Evolution, Molecular
Genetic drift
Phylogenetics
Virology
medicine
Influenza A virus
Animals
lcsh:RC109-216
Selection, Genetic
Mexico
Gene
Phylogeny
Genetic Drift
virus diseases
Sequence Analysis, DNA
Influenza A virus subtype H5N1
Vaccination
Infectious Diseases
Influenza Vaccines
Influenza in Birds
biology.protein
Influenza A Virus, H5N2 Subtype
Chickens
Subjects
Details
- Language :
- English
- ISSN :
- 1743422X
- Volume :
- 5
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Virology Journal
- Accession number :
- edsair.doi.dedup.....310a08a98236ba0df9c460aa42d8d779
- Full Text :
- https://doi.org/10.1186/1743-422x-5-15