Back to Search
Start Over
Poor catch-up growth after proctocolectomy in pediatric patients with ulcerative colitis receiving prolonged steroid therapy
- Source :
- Pediatric surgery international. 26(4)
- Publication Year :
- 2010
-
Abstract
- The aim of the present study was to review the complications and growth after proctocolectomy and ileal J-pouch anal anastomosis (IPAA) in pediatric ulcerative colitis (UC) patients receiving prolonged steroid therapy.We experienced 209 patients with UC who received IPAA between September 2000 and June 2009, and reviewed the medical records of 16 pediatric (15 years of age at operation and1 year follow-up) patients.The total dose of preoperative prednisolone (PSL) was 9,829 +/- 9,283 mg (mean +/- 1SD 880-30,000 mg). The dose of preoperative PSL was significantly related to the occurrence of preoperative major steroid-related complications (SRC). Older patients (11 years at operation) grew more slowly compared with younger patients (or =11 years at operation) for 5 years. There was a significant difference in height between PSL high-dose (10,000 mg) and PSL low-dose (or =10,000) patients for 5 years after colectomy. The mean height of PSL high-dose patients did not reach the standard level during the 5-year follow-up.Preoperative prolonged high steroid therapy may disturb growth recovery of pediatric patients with UC, while early induction of colectomy allowed pediatric patients with PSL dependency to become free of steroids and get normal growth.
- Subjects :
- Male
medicine.medical_specialty
Adolescent
medicine.medical_treatment
Prednisolone
Pediatric ulcerative colitis
Anastomosis
Gastroenterology
Time
Young Adult
Postoperative Complications
Internal medicine
Pediatric surgery
Medicine
Humans
Growth Charts
Child
Glucocorticoids
Retrospective Studies
Dose-Response Relationship, Drug
business.industry
Proctocolectomy
Proctocolectomy, Restorative
Infant
General Medicine
medicine.disease
Ulcerative colitis
Body Height
Surgery
Steroid therapy
Child, Preschool
Pediatrics, Perinatology and Child Health
Colitis, Ulcerative
Female
business
Follow-Up Studies
Subjects
Details
- ISSN :
- 14379813
- Volume :
- 26
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Pediatric surgery international
- Accession number :
- edsair.doi.dedup.....31066ba627c08d2bc4a7f712c79e7bbe