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Effect of local treatment for metastasis and its sequence with chemotherapy on prognosis of post-treatment metastatic nasopharyngeal carcinoma patients
- Source :
- Oral oncology. 92
- Publication Year :
- 2018
-
Abstract
- Background Distant metastasis after chemoradiotherapy remains the leading cause of death in NPC patients. But the effect of local treatment for metastatic sites and its sequence with chemotherapy on prognosis of them are poorly documented. Methods 448 post-treatment metastatic NPC patients were included in our retrospective study. And Cox regression and log-rank tests were applied to investigate the association between topical treatment and its sequence with chemotherapy and survival using the propensity score method (PSM) to adjust for gender, age, Tumor stage, Node stage, metastatic sites, diabetes and smoking with a 1:2 matching protocol. Results The 3-year OS was significantly higher in patients who received local treatment of distant metastasis compared with patients who did not (48.8% vs 33.8%, P = 0.001) in primary cohort. PSM identified 120 patients in the cohort with local treatment and 240 in that without and similar survival benefits were observed for the local treatment (3-year OS: 36.2% versus 48.8%, P = 0.011). Subgroup analyses indicated that there was no significant survival difference in patients with different treatment sequence. Conclusions In conclusion, post-treatment metastatic NPC patients could be beneficial from local treatment for metastasis but its sequence with palliative chemotherapy does not affect overall survival.
- Subjects :
- Oncology
Adult
Diagnostic Imaging
Male
Cancer Research
medicine.medical_specialty
medicine.medical_treatment
Kaplan-Meier Estimate
Metastasis
03 medical and health sciences
0302 clinical medicine
Internal medicine
Antineoplastic Combined Chemotherapy Protocols
medicine
Humans
Stage (cooking)
Neoplasm Metastasis
030223 otorhinolaryngology
Neoplasm Staging
Proportional Hazards Models
Retrospective Studies
Chemotherapy
Nasopharyngeal Carcinoma
business.industry
Proportional hazards model
Carcinoma
Retrospective cohort study
Middle Aged
medicine.disease
Prognosis
Treatment Outcome
Nasopharyngeal carcinoma
030220 oncology & carcinogenesis
Cohort
Female
Oral Surgery
business
Chemoradiotherapy
Subjects
Details
- ISSN :
- 18790593
- Volume :
- 92
- Database :
- OpenAIRE
- Journal :
- Oral oncology
- Accession number :
- edsair.doi.dedup.....30fcb7f64cb5dc4d36d34664e9ccd6ab