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The evolutionary history of the amylase multigene family in Drosophila pseudoobscura
- Source :
- Molecular Biology and Evolution. 13:883-888
- Publication Year :
- 1996
- Publisher :
- Oxford University Press (OUP), 1996.
-
Abstract
- In Drosophila pseudoobscura, the amylase (Amy) multigene family is contained within a series of inversions, or gene arrangements, on the third chromosome. The Standard (ST), Santa Cruz (SC), and Tree Line (TL) inversions are central to the phylogeny of arrangements, and have clusters of other arrangements derived from them. The gene arrangements belonging to each of these three clusters have a characteristic number of Amy genes, ranging from three in ST to two in SC to one in TL. This distribution pattern can reflect a history of either duplications or deletions, although the data available in the past did not permit a decision between these alternatives. We provide unambiguous evidence that three Amy genes were present before the divergence of the ST, SC, and TL arrangements. Thus, the current status of the Amy multigene family is the result of deletions in the TL and SC arrangements, which created three new pseudogenes: TL Amy2-psi, TL Amy3-psi, and SC Amy3-psi. Analysis of pseudogene sequences revealed that, in the SC and ST arrangements, pseudogene evolution has been retarded, most likely due to the homogenization effect of gene conversion. Finally, by determining the original copy number, we have reconstructed the evolutionary history of the Amy multigene family and linked it with the evolution of the central gene arrangements.
- Subjects :
- Pseudogene
Molecular Sequence Data
Genes, Insect
Evolution, Molecular
Drosophila pseudoobscura
Phylogenetics
Genetics
Animals
Gene conversion
Cloning, Molecular
Drosophila (subgenus)
Molecular Biology
Gene
Phylogeny
Ecology, Evolution, Behavior and Systematics
Sequence Deletion
Base Sequence
biology
Chromosome Mapping
Chromosome
biology.organism_classification
Multigene Family
Chromosome Inversion
Gene Arrangements
Drosophila
alpha-Amylases
Pseudogenes
Subjects
Details
- ISSN :
- 15371719 and 07374038
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- Molecular Biology and Evolution
- Accession number :
- edsair.doi.dedup.....30f3284e9f6afa61a58e68c528a59b18