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Energy restriction and Roux-en-Y gastric bypass reduce postprandial α-dicarbonyl stress in obese women with type 2 diabetes
- Source :
- Diabetologia, Diabetologia, 59(9), 2013-2017. SPRINGER, Diabetologia, 59(9), 2013-2017. Springer, Cham
- Publication Year :
- 2016
- Publisher :
- Springer Berlin Heidelberg, 2016.
-
Abstract
- Aims/hypothesis Dicarbonyl compounds are formed as byproducts of glycolysis and are key mediators of diabetic complications. However, evidence of postprandial α-dicarbonyl formation in humans is lacking, and interventions to reduce α-dicarbonyls have not yet been investigated. Therefore, we investigated postprandial α-dicarbonyl levels in obese women without and with type 2 diabetes. Furthermore, we evaluated whether a diet very low in energy (very low calorie diet [VLCD]) or Roux-en-Y gastric bypass (RYGB) reduces α-dicarbonyl stress in obese women with type 2 diabetes. Methods In lean (n = 12) and obese women without (n = 27) or with type 2 diabetes (n = 27), we measured the α-dicarbonyls, methylglyoxal (MGO), glyoxal (GO) and 3-deoxyglucosone (3-DG), and glucose in fasting and postprandial plasma samples obtained during a mixed meal test. Obese women with type 2 diabetes underwent either a VLCD or RYGB. Three weeks after the intervention, individuals underwent a second mixed meal test. Results Obese women with type 2 diabetes had higher fasting and particularly higher postprandial plasma α-dicarbonyl levels, compared with those without diabetes. After three weeks of a VLCD, postprandial α-dicarbonyl levels in diabetic women were significantly reduced (AUC MGO −14%, GO −16%, 3-DG −25%), mainly through reduction of fasting plasma α-dicarbonyls (MGO −13%, GO −13%, 3-DG −33%). Similar results were found after RYGB. Conclusions/interpretation This study shows that type 2 diabetes is characterised by increased fasting and postprandial plasma α-dicarbonyl stress, which can be reduced by improving glucose metabolism through a VLCD or RYGB. These data highlight the potential to reduce reactive α-dicarbonyls in obese individuals with type 2 diabetes. Trial registration: ClinicalTrials.gov NCT01167959 Electronic supplementary material The online version of this article (doi:10.1007/s00125-016-4009-1) contains peer-reviewed but unedited supplementary material, which is available to authorised users.
- Subjects :
- 0301 basic medicine
Adult
medicine.medical_specialty
food.diet
Endocrinology, Diabetes and Metabolism
Short Communication
Gastric bypass
Gastric Bypass
030209 endocrinology & metabolism
Type 2 diabetes
medicine.disease_cause
03 medical and health sciences
alpha-Dicarbonyls
0302 clinical medicine
food
Internal medicine
Internal Medicine
Medicine
Humans
Glycolysis
Weight loss interventions
Obesity
Caloric Restriction
business.industry
Advanced glycation endproducts
Fasting
Middle Aged
medicine.disease
Postprandial Period
Roux-en-Y anastomosis
Very low calorie diet
Oxidative Stress
030104 developmental biology
Endocrinology
Postprandial
Diabetes Mellitus, Type 2
α-Dicarbonyls
Female
business
Oxidative stress
Subjects
Details
- Language :
- English
- ISSN :
- 14320428 and 0012186X
- Volume :
- 59
- Database :
- OpenAIRE
- Journal :
- Diabetologia
- Accession number :
- edsair.doi.dedup.....30efce5bb082ec4c157c2862a3233667