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Is glutamate associated with fear extinction and cognitive behavior therapy outcome in OCD? A pilot study
- Source :
- European archives of psychiatry and clinical neuroscience, r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu, instname, r-FSJD: Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu, Fundació Sant Joan de Déu
- Publication Year :
- 2019
- Publisher :
- Springer Science and Business Media LLC, 2019.
-
Abstract
- Cognitive behavioral therapy (CBT) including exposure and response prevention is a well-established treatment for obsessive-compulsive disorder (OCD) and is based on the principles of fear extinction. Fear extinction is linked to structural and functional variability in the ventromedial prefrontal cortex (vmPFC) and has been consistently associated with glutamate neurotransmission. The relationship between vmPFC glutamate and fear extinction and its effects on CBT outcome have not yet been explored in adults with OCD. We assessed glutamate levels in the vmPFC using 3T magnetic resonance spectroscopy, and fear extinction (learning and recall) using skin conductance responses during a 2-day experimental paradigm in OCD patients (n = 17) and in healthy controls (HC; n = 13). Obsessive-compulsive patients (n = 12) then received manualized CBT. Glutamate in the vmPFC was negatively associated with fear extinction recall and positively associated with CBT outcome (with higher glutamate levels predicting a better outcome) in OCD patients. Glutamate levels in the vmPFC in OCD patients were not significantly different from those in HC, and were not associated with OCD severity. Our results suggest that glutamate in the vmPFC is associated with fear extinction recall and CBT outcome in adult OCD patients.
- Subjects :
- Adult
Male
Obsessive-Compulsive Disorder
Magnetic Resonance Spectroscopy
medicine.medical_treatment
Ventromedial prefrontal cortex
Glutamic Acid
Prefrontal Cortex
Pilot Projects
Ventromedial prefrontal cortex (vmPFC)
Severity of Illness Index
behavioral disciplines and activities
Extinction, Psychological
Young Adult
03 medical and health sciences
Obsessive–compulsive disorder (OCD)
0302 clinical medicine
Outcome Assessment, Health Care
mental disorders
medicine
Humans
Pharmacology (medical)
Obsessive-compulsive disorder (OCD)
Biological Psychiatry
Cognitive behavioral therapy (CBT)
Cognitive Behavioral Therapy
Recall
business.industry
Glutamate receptor
Cognition
Fear
Galvanic Skin Response
General Medicine
Extinction (psychology)
Middle Aged
medicine.disease
humanities
030227 psychiatry
Exposure and response prevention
Cognitive behavioral therapy
Psychiatry and Mental health
Fear extinction
medicine.anatomical_structure
Female
Glutamate
business
030217 neurology & neurosurgery
Clinical psychology
Subjects
Details
- ISSN :
- 14338491 and 09401334
- Volume :
- 270
- Database :
- OpenAIRE
- Journal :
- European Archives of Psychiatry and Clinical Neuroscience
- Accession number :
- edsair.doi.dedup.....30e582ad4204cda3518f29ce63b17e6b