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Epstein-barr virus-related ultrastructural modifications of plasma membrane during B-cell transformation
- Source :
- International Journal of Cancer. 38:549-552
- Publication Year :
- 1986
- Publisher :
- Wiley, 1986.
-
Abstract
- Ultrastructural modifications are described in the plasma membrane of in vitro established human B cells. By the freeze-fracture technique, intramembrane particles (IMPs) are quantified in B lymphocytes following Epstein-Barr virus (EBV) transformation in vitro, and in B-lymphoma (Burkitt-type) cells, either positive or negative for EBV genome. Analysis shows an overall increase in IMP density as compared to normal controls. Differences are observed between the protoplasmic and exoplasmic faces of fractured membranes as well as among in vitro transformed and clearly neoplastic cells. Results indicate that conformational changes in IMP distribution parallel neoplastic evolution of transformed cells.
- Subjects :
- B-Lymphocytes
Herpesvirus 4, Human
Cancer Research
Cell Membrane
Biology
Cell Transformation, Viral
medicine.disease_cause
Burkitt Lymphoma
Epstein–Barr virus
In vitro
Virus
Cell biology
Protoplasm
Microscopy, Electron
Transformation (genetics)
Membrane
medicine.anatomical_structure
Oncology
hemic and lymphatic diseases
Image Processing, Computer-Assisted
Ultrastructure
medicine
Freeze Fracturing
Humans
B cell
Subjects
Details
- ISSN :
- 10970215 and 00207136
- Volume :
- 38
- Database :
- OpenAIRE
- Journal :
- International Journal of Cancer
- Accession number :
- edsair.doi.dedup.....30e40a414a864050e22dd680ff07e804