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Copeptin, a surrogate marker for arginine vasopressin, is associated with declining glomerular filtration in patients with diabetes mellitus (ZODIAC-33)
- Source :
- Diabetologia, 56(8), 1680-1688. SPRINGER
- Publication Year :
- 2012
-
Abstract
- Arginine vasopressin (AVP), the hormone important for maintaining fluid balance, has been shown to cause kidney damage in rodent models of diabetes. We investigated the potential role of AVP in the natural course of kidney function decline in diabetes in an epidemiological study.Plasma copeptin, a surrogate for AVP, was measured in baseline samples from patients with type 2 diabetes treated in primary care and included in the Zwolle Outpatient Diabetes project Integrating Available Care (ZODIAC) cohort.Samples from 1,328 patients were available; 349 were analysed separately because they used renin-angiotensin-aldosterone system inhibition (RAASi), which influences albumin/creatinine ratio (ACR) and estimated (e)GFR. In the other 979 patients (46% men, age 68 years [58-75], ACR 1.8 mg/mmol [0.9-5.7], eGFR 67 +/- 14 ml min(-1) 1.73 m(-2)) baseline copeptin (5.3 pmol/l [3.2-9.5]) was significantly associated with log (e) [ACR] and eGFR, even after adjustment for sex, age and risk factors for kidney function decline (standardised [std] beta 0.13, p In patients with diabetes not using RAASi a higher baseline copeptin concentration is significantly associated with higher baseline ACR and lower eGFR values and with a decline in eGFR during follow-up. This last association is independent of, and stronger than, most traditional risk factors for kidney function decline.
- Subjects :
- Male
Vasopressin
Endocrinology, Diabetes and Metabolism
Angiotensin-Converting Enzyme Inhibitors
Diabetic nephropathy
Albumin/creatinine ratio
POLYCYSTIC KIDNEY-DISEASE
Renin-Angiotensin System
Polycystic kidney disease
EQUATION
PLASMA VASOPRESSIN
Estimated glomerular filtration rate
Kidney
Glycopeptides
Middle Aged
RECEPTORS
medicine.anatomical_structure
Creatinine
BRATTLEBORO RATS
Female
hormones, hormone substitutes, and hormone antagonists
Glomerular Filtration Rate
endocrine system
medicine.medical_specialty
OSMOLALITY
RENAL-FAILURE
Renal function
Copeptin
Kidney function
Diabetes mellitus
Internal medicine
Albumins
Type 2 diabetes mellitus
Internal Medicine
medicine
Humans
Aged
urogenital system
business.industry
MICROALBUMINURIA
Type 2 Diabetes Mellitus
URINARY ALBUMIN EXCRETION
medicine.disease
Arginine Vasopressin
Endocrinology
Cross-Sectional Studies
Diabetes Mellitus, Type 2
business
Biomarkers
Subjects
Details
- ISSN :
- 14320428 and 0012186X
- Volume :
- 56
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- Diabetologia
- Accession number :
- edsair.doi.dedup.....30db6ca4434333d586fc5e4237499467