Dopamine Transporter Imaging Using 99mTc-TRODAT-1 SPECT in Parkinson’s Disease

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Background: Although the decrease in striatal dopamine transporter (DAT) density has been described in North American, European, and Asian Parkinson's disease (PD) patients, studies on this issue are required in the rest of the world. This study examined the diagnostic utility of DAT imaging in Brazilian PD patients.Material/Methods: Twenty PD patients (13 males, 7 females, median age: 62 years, median age at disease onset: 56 years, median disease duration: 5 years, and median UPDRS-III score: 29) and 9 age-and sex-matched healthy subjects underwent single-photon emission computerized tomography (SPECT) using Tc-99m-TRODAT-1.Results: PD patients showed a significant decrease in the striatum, caudate nucleus, and putamen DAT densities compared with data from healthy subjects. Striatal Tc-99m-TRODAT-1 bindings had the highest diagnostic accuracy compared to those estimates from caudate nucleus and putamen. For the diagnosis of PD, a striatal Tc-99m-TRODAT-1 binding cut-off value of 0.90 was associated with a sensitivity of 100% and a specificity of 89%. There was no significant difference between striatal Tc-99m-TRODAT-1 binding values provided by different readers, contrary to Tc-99m-TRODAT-1 binding estimates in the caudate nucleus.Conclusions: Striatal DAT imaging using Tc-99m-TRODAT-1 can be considered a marker for differentiating PD patients from healthy individuals, with a good interobserver reproducibility. Univ Sao Paulo, Sch Med, Hosp Clin, Dept Neurol Surg, Sao Paulo, Brazil Univ Fed Sao Paulo, Dept Neurol & Neurosurg, Sao Paulo, Brazil Univ Fed Sao Paulo, Dept Psychiat, Sao Paulo, Brazil Hosp Israelita Albert Einstein, Dept Neurol, Sao Paulo, Brazil Univ Fed Sao Paulo, Dept Neurol & Neurosurg, Sao Paulo, Brazil Univ Fed Sao Paulo, Dept Psychiat, Sao Paulo, Brazil Web of Science