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Aerobic exercise training-induced changes in serum C1q/TNF-related protein levels are associated with reduced arterial stiffness in middle-aged and older adults
- Source :
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 314:R94-R101
- Publication Year :
- 2018
- Publisher :
- American Physiological Society, 2018.
-
Abstract
- Adiponectin regulates endothelial nitric oxide synthase in endothelial cells, and body fat loss by aerobic exercise training promotes adiponectin secretion. Recently, C1q/tumor necrosis factor-related proteins (CTRPs) have been identified as novel adipokines and are paralogs of adiponectin, but the association between exercise training-induced reduction of arterial stiffness and circulating CTRPs levels remains unclear. This study aimed to clarify whether the reduction of arterial stiffness in middle-aged and older adults is associated with the change in serum levels of CTRPs induced by exercise training. A total of 52 middle-aged and older participants were randomly divided into two groups: a training group ( n = 26) and a sedentary control group ( n = 26). Participants in the training group completed 8 wk of aerobic exercise training (60–70% peak oxygen uptake for 45 min, 3 days/wk). The reduction of percent whole body fat, abdominal visceral fat area, and carotid-femoral pulse-wave velocity (cfPWV) was significantly greater in the training group than in the control group ( P < 0.05). Moreover, the increase in serum adiponectin, CTRP3, and CTRP5 from baseline to 8 wk was significantly higher in the training group compared with the control group ( P < 0.05). Additionally, the training-induced change in cfPWV was negatively correlated with the training-induced change in serum adiponectin, CTRP3, and CTRP5 levels ( r = −0.51, r = −0.48, r = −0.42, respectively, P < 0.05), and increased plasma nitrite/nitrate level by exercise training was correlated only with adiponectin levels ( r = 0.41, P < 0.05). These results suggest that the exercise training-induced increase in serum CTRPs levels may be associated with the reduction of arterial stiffness in middle-aged and older adults.
- Subjects :
- Male
0301 basic medicine
Aging
medicine.medical_specialty
Time Factors
Physiology
Adipokine
Pulse Wave Analysis
030204 cardiovascular system & hematology
03 medical and health sciences
Oxygen Consumption
Vascular Stiffness
0302 clinical medicine
Downregulation and upregulation
Physiology (medical)
Internal medicine
medicine
Humans
Aerobic exercise
Adiponectin secretion
Geriatric Assessment
Adiposity
Aged
Glycoproteins
Exercise Tolerance
Adiponectin
Endothelial nitric oxide synthase
business.industry
Age Factors
Middle Aged
medicine.disease
Tumor Necrosis Factor Receptor-Associated Peptides and Proteins
Exercise Therapy
Up-Regulation
Treatment Outcome
030104 developmental biology
Endocrinology
Cardiovascular Diseases
Tumor Necrosis Factors
Arterial stiffness
Female
Tumor necrosis factor alpha
Collagen
business
Biomarkers
Subjects
Details
- ISSN :
- 15221490 and 03636119
- Volume :
- 314
- Database :
- OpenAIRE
- Journal :
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
- Accession number :
- edsair.doi.dedup.....30b28d820bcab01ecec4a38ebba7a112