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IGF-I treatment facilitates transition from parenteral to enteral nutrition in rats with short bowel syndrome
- Source :
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 284:R363-R371
- Publication Year :
- 2003
- Publisher :
- American Physiological Society, 2003.
-
Abstract
- The goal of growth factor treatment in patients with short bowel syndrome (SBS) is to facilitate transition from parenteral to enteral feedings. Ideal use of growth factors would be acute treatment that produces sustained effects. We investigated the ability of acute insulin-like growth factor I (IGF-I) treatment to facilitate weaning from total parenteral nutrition (TPN) to enteral feeding in a rat model of SBS. After a 60% jejunoileal resection + cecectomy, rats treated with IGF-I or vehicle were maintained exclusively with TPN for 4 days and transitioned to oral feeding. TPN and IGF-I were stopped 7 days after resection, and rats were maintained with oral feeding for 10 more days. In IGF-I-treated rats, serum concentration of IGF-I and final body weight were significantly greater because of a proportionate increase in carcass lean body mass than in vehicle-treated rats. Acute IGF-I treatment induced sustained jejunal hyperplasia on the basis of significantly greater concentrations of jejunal mucosal protein and DNA without a change in histology or sucrase activity. These results demonstrate that acute IGF-I facilitates weaning from parenteral to enteral nutrition in association with maintenance of a greater body weight and serum IGF-I concentration in rats with SBS.
- Subjects :
- Male
Short Bowel Syndrome
Parenteral Nutrition
medicine.medical_specialty
Colon
Physiology
medicine.medical_treatment
Gastroenterology
Enteral administration
Rats, Sprague-Dawley
Enteral Nutrition
Physiology (medical)
Internal medicine
Animals
Weaning
Medicine
RNA, Messenger
Insulin-Like Growth Factor I
Intestinal Mucosa
business.industry
Growth factor
Body Weight
Organ Size
Hyperplasia
medicine.disease
Short bowel syndrome
Rats
Disease Models, Animal
Jejunum
Endocrinology
Parenteral nutrition
Sucrase activity
Body Composition
Lean body mass
Energy Metabolism
business
Sucrase
Subjects
Details
- ISSN :
- 15221490 and 03636119
- Volume :
- 284
- Database :
- OpenAIRE
- Journal :
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
- Accession number :
- edsair.doi.dedup.....309863a1513119523bc490ea7ee42527