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Antioxidant Activity of Diphenylpropionamide Derivatives: Synthesis, Biological Evaluation and Computational Analysis
- Source :
- Molecules (Basel, Online) 13 (2008): 749–761. doi:10.3390/molecules13040749, info:cnr-pdr/source/autori:Urbani P.; Ramunno A.; Filosa R.; Pinto A.; Popolo A.; Bianchino E.; Piotto S.; Saturnino C.; De Prisco R.; Nicolaus B; Tommonaro G./titolo:Antioxidant Activity of Diphenylpropionamide Derivatives: Synthesis, Biological Evaluation and Computational Analysis/doi:10.3390%2Fmolecules13040749/rivista:Molecules (Basel, Online)/anno:2008/pagina_da:749/pagina_a:761/intervallo_pagine:749–761/volume:13, Molecules; Volume 13; Issue 4; Pages: 749-761, Molecules, Molecules, Vol 13, Iss 4, Pp 749-761 (2008)
- Publication Year :
- 2008
- Publisher :
- MDPI AG, 2008.
-
Abstract
- We report the synthesis, antioxidant and antiproliferative activity and a QSAR analysis of synthetic diphenylpropionamide derivatives. Synthesis of these compounds was achieved by direct condensation of 2,2- and 3,3-diphenylpropionic acid and appropriate amines using 1-propylphoshonic acid cyclic anhydride (PPAA) as catalyst. Compound structures were elucidated by NMR analysis and their melting points were measured. The in vitro antioxidant activity of these compounds was tested by evaluating the amount of scavenged ABTS radical and estimating ROS and NO production in LPS stimulated J774.A1 macrophages. All compounds were tested for their effect on viability of cells and results demonstrated that they are not toxic towards the cell lines used. The cytotoxic activity of all compounds was evaluated by a Brine Shrimp Test.
- Subjects :
- Lipopolysaccharides
Diphenylpropionamide derivatives
Antioxidant
medicine.medical_treatment
antioxidant activity
brine shrimp test
Pharmaceutical Science
Antioxidants
Analytical Chemistry
Mice
diphenylpropionamide derivative
chemistry.chemical_compound
Drug Discovery
Organic chemistry
Cytotoxic T cell
ABTS
Full Paper
biology
ROS
J774.A1 macrophages
antiproliferative activity
QSAR analysis
Chemistry (miscellaneous)
Molecular Medicine
Quantitative structure–activity relationship
LPS
Brine shrimp
Nitric Oxide
NO
Catalysis
lcsh:QD241-441
lcsh:Organic chemistry
medicine
Animals
Physical and Theoretical Chemistry
cytotoxic activity
Cell Proliferation
Macrophages
Organic Chemistry
synthetic diphenylpropionamide derivatives, ROS, NO, LPS, J774.A1 macrophages, cytotoxic activity, Brine Shrimp Test
Computational Biology
biology.organism_classification
Amides
In vitro
synthetic diphenylpropionamide derivatives
chemistry
Cell culture
Propionates
Reactive Oxygen Species
Subjects
Details
- ISSN :
- 14203049
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- Molecules
- Accession number :
- edsair.doi.dedup.....309784e78b118d0e60c2efd702ad1454