Monitored Daily Ambulatory Activity, Inflammation, and Oxidative Stress in Patients With Claudication

We determined the association between daily ambulatory activity and markers of inflammation and oxidative stress in patients with peripheral artery disease (PAD) and claudication. Patients with PAD (n = 134) limited by claudication were studied. Patients took 3275 ± 1743 daily strides for 273 ± 112 minutes each day, and their average daily cadence was 11.7 ± 2.7 strides/min. High-sensitivity C-reactive protein was significantly and negatively associated with the total number of daily strides ( P < .001), total daily ambulatory time ( P < .01), peak activity index ( P < .01), daily average cadence ( P < .05), and the maximum cadences for 60 minutes ( P < .05), 30 minutes ( P < .05), 20 minutes ( P < .05), and 5 minutes ( P < .01). Oxidized low-density lipoprotein and soluble vascular cell adhesion molecule 1 were not significantly associated with any of the ambulatory measures ( P > .05). We conclude that higher levels of community-based, daily ambulatory activity are associated with lower levels of inflammation but are not associated with markers of oxidative stress.