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A Review on the Development of Gold and Silver Nanoparticles-Based Biosensor as a Detection Strategy of Emerging and Pathogenic RNA Virus
- Source :
- Sensors, Vol 21, Iss 5114, p 5114 (2021), Sensors (Basel, Switzerland)
- Publication Year :
- 2021
- Publisher :
- MDPI AG, 2021.
-
Abstract
- The emergence of highly pathogenic and deadly human coronaviruses, namely SARS-CoV and MERS-CoV within the past two decades and currently SARS-CoV-2, have resulted in millions of human death across the world. In addition, other human viral diseases, such as mosquito borne-viral diseases and blood-borne viruses, also contribute to a higher risk of death in severe cases. To date, there is no specific drug or medicine available to cure these human viral diseases. Therefore, the early and rapid detection without compromising the test accuracy is required in order to provide a suitable treatment for the containment of the diseases. Recently, nanomaterials-based biosensors have attracted enormous interest due to their biological activities and unique sensing properties, which enable the detection of analytes such as nucleic acid (DNA or RNA), aptamers, and proteins in clinical samples. In addition, the advances of nanotechnologies also enable the development of miniaturized detection systems for point-of-care (POC) biosensors, which could be a new strategy for detecting human viral diseases. The detection of virus-specific genes by using single-stranded DNA (ssDNA) probes has become a particular interest due to their higher sensitivity and specificity compared to immunological methods based on antibody or antigen for early diagnosis of viral infection. Hence, this review has been developed to provide an overview of the current development of nanoparticles-based biosensors that target pathogenic RNA viruses, toward a robust and effective detection strategy of the existing or newly emerging human viral diseases such as SARS-CoV-2. This review emphasizes the nanoparticles-based biosensors developed using noble metals such as gold (Au) and silver (Ag) by virtue of their powerful characteristics as a signal amplifier or enhancer in the detection of nucleic acid. In addition, this review provides a broad knowledge with respect to several analytical methods involved in the development of nanoparticles-based biosensors for the detection of viral nucleic acid using both optical and electrochemical techniques.
- Subjects :
- Silver
Aptamer
viruses
Metal Nanoparticles
Review
Biosensing Techniques
02 engineering and technology
Computational biology
TP1-1185
Biology
biosensor
01 natural sciences
Biochemistry
electrochemical biosensing
Silver nanoparticle
Analytical Chemistry
chemistry.chemical_compound
Animals
Humans
Electrical and Electronic Engineering
Instrumentation
plasmonic
SARS-CoV-2
Chemical technology
010401 analytical chemistry
COVID-19
RNA
RNA virus
021001 nanoscience & nanotechnology
biology.organism_classification
viral disease
Atomic and Molecular Physics, and Optics
0104 chemical sciences
nucleic acid
chemistry
Nucleic acid
nanoparticles
Gold
Viral disease
0210 nano-technology
Biosensor
DNA
Subjects
Details
- Language :
- English
- ISSN :
- 14248220
- Volume :
- 21
- Issue :
- 5114
- Database :
- OpenAIRE
- Journal :
- Sensors
- Accession number :
- edsair.doi.dedup.....308e432d241c9b90de44536d4c742fa5