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Separate synthesis and evaluation of glucitol bis-phosphate and mannitol bis-phosphate, as competitive inhibitors of fructose bis-phosphate aldolases
- Source :
- Bioorganicmedicinal chemistry letters. 18(5)
- Publication Year :
- 2007
-
Abstract
- We report the first unambiguous syntheses of glucitol-1,6-bis-phosphate and mannitol-1,6-bis-phosphate and their competitive inhibition of various fructose bis-phosphate aldolases.
- Subjects :
- Clinical Biochemistry
Pharmaceutical Science
Fructose-bisphosphate aldolase
Saccharomyces cerevisiae
Biochemistry
Chemical synthesis
chemistry.chemical_compound
Non-competitive inhibition
Fructose-Bisphosphate Aldolase
Drug Discovery
medicine
Organic chemistry
Sorbitol
Molecular Biology
Antibacterial agent
biology
Helicobacter pylori
Molecular Structure
Organic Chemistry
Aldolase A
Fructose
Phosphate
Mannitol Phosphates
Anti-Bacterial Agents
chemistry
biology.protein
Molecular Medicine
Sugar Phosphates
Mannitol
medicine.drug
Subjects
Details
- ISSN :
- 14643405
- Volume :
- 18
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Bioorganicmedicinal chemistry letters
- Accession number :
- edsair.doi.dedup.....308d2ae53421a9aa64558ba06fd60f07