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Complete response of advanced hepatocellular carcinoma with multiple lung metastases treated with sorafenib: a case report
- Source :
- Oncology. 81
- Publication Year :
- 2012
-
Abstract
- Sorafenib, an oral multikinase inhibitor, has demonstrated clinical efficacy in patients with advanced hepatocellular carcinoma (HCC). However, in the SHARP trial (Sorafenib HCC Assessment Randomized Protocol trial) and the Asia-Pacific trial (conducted in the Asia-Pacific region), no cases of complete response (CR) were reported. Thereafter, only a relatively small number of CR cases were reported worldwide for sorafenib therapy. We herein report a case of CR in a patient treated with sorafenib for 4 months. The patient had advanced HCC with multiple lung metastases, and there has been no recurrence after 8 months following cessation of administration. To our knowledge, this is the first time a female treated with sorafenib alone for HCC has had a CR.
- Subjects :
- Oncology
Sorafenib
Niacinamide
Cancer Research
medicine.medical_specialty
Carcinoma, Hepatocellular
Lung Neoplasms
Pyridines
Antineoplastic Agents
urologic and male genital diseases
Multikinase inhibitor
Internal medicine
Carcinoma
Medicine
Humans
heterocyclic compounds
In patient
Clinical efficacy
neoplasms
Protein Kinase Inhibitors
Complete response
Aged
Lung
business.industry
Phenylurea Compounds
Benzenesulfonates
Liver Neoplasms
Remission Induction
General Medicine
medicine.disease
female genital diseases and pregnancy complications
digestive system diseases
medicine.anatomical_structure
Treatment Outcome
Hepatocellular carcinoma
Female
business
medicine.drug
Subjects
Details
- ISSN :
- 14230232
- Volume :
- 81
- Database :
- OpenAIRE
- Journal :
- Oncology
- Accession number :
- edsair.doi.dedup.....30780e5fb7dc44c44537051d74960222