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Paper-based microfluidic device for diagnosis of osteoporosis markers
- Source :
- Bioanalysis. 10(20)
- Publication Year :
- 2018
-
Abstract
- Background: Development of cost-effective platforms for identification of biomarkers is of paramount importance in low-income settings. The present work focuses on the development of a microfluidic paper-based analytical device (μPADs) for the diagnosis of osteoporosis by measuring three important bone biomarkers – calcium, alkaline phosphatase and vitamin D. Methods: Antibody-based detection is realized in μPAD reservoirs based on principle of colorimetric sensing, where μPAD images are captured using a smartphone. The results are compared with the calibration curves to give proper quantification of analytes. Conclusion: This device can be potentially developed into a point-of-care diagnostic device for low-income settings. To the best of our understanding, a μPAD platform for simultaneous diagnosis of multiple osteoporosis markers is not reported yet.
- Subjects :
- Paper
Computer science
Point-of-Care Systems
Clinical Biochemistry
Microfluidics
Biomedical Engineering
02 engineering and technology
01 natural sciences
Sensitivity and Specificity
Analytical Chemistry
Lab-On-A-Chip Devices
Humans
General Pharmacology, Toxicology and Pharmaceutics
Vitamin D
Point of care
010401 analytical chemistry
General Medicine
Paper based
Equipment Design
021001 nanoscience & nanotechnology
Alkaline Phosphatase
0104 chemical sciences
Medical Laboratory Technology
Calibration
Systems engineering
Osteoporosis
Identification (biology)
Calcium
Colorimetry
Smartphone
0210 nano-technology
Subjects
Details
- ISSN :
- 17576199
- Volume :
- 10
- Issue :
- 20
- Database :
- OpenAIRE
- Journal :
- Bioanalysis
- Accession number :
- edsair.doi.dedup.....3075523f6a8e46621d2d6386de8c16bb