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Reduction in labile plasma iron during treatment with deferasirox, a once-daily oral iron chelator, in heavily iron-overloaded patients with β-thalassaemia
- Source :
- European Journal of Haematology
- Publication Year :
- 2009
- Publisher :
- Blackwell Publishing Ltd, 2009.
-
Abstract
- This subgroup analysis evaluated the effect of once-daily oral deferasirox on labile plasma iron (LPI) levels in patients from the prospective, 1-yr, multicentre ESCALATOR study. Mean baseline liver iron concentration and median serum ferritin levels were 28.6 +/- 10.3 mg Fe/g dry weight and 6334 ng/mL respectively, indicating high iron burden despite prior chelation therapy. Baseline LPI levels (0.98 +/- 0.82 micromol/L) decreased significantly to 0.12 +/- 0.16 micromol/L, 2 h after first deferasirox dose (P = 0.0006). Reductions from pre- to post-deferasirox administration were also observed at all other time points. Compared to baseline, there was a significant reduction in preadministration LPI that reached the normal range at week 4 and throughout the remainder of the study (Por = 0.02). Pharmacokinetic analysis demonstrated an inverse relationship between preadministration LPI levels and trough deferasirox plasma concentrations. Once-daily dosing with deferasiroxor =20 mg/kg/d provided sustained reduction in LPI levels in these heavily iron-overloaded patients, suggesting 24-h protection from LPI. Deferasirox may therefore reduce unregulated tissue iron loading and prevent further end-organ damage.
- Subjects :
- Adult
Male
medicine.medical_specialty
Liver Iron Concentration
Iron Overload
Adolescent
Iron
Iron Chelating Agents
Gastroenterology
Benzoates
oral
Young Adult
Pharmacokinetics
Internal medicine
labile plasma iron
medicine
Humans
Dosing
Chelation therapy
pharmacokinetic
Child
business.industry
Deferasirox
beta-Thalassemia
Beta thalassemia
Hematology
General Medicine
Original Articles
β-thalassaemia
Triazoles
medicine.disease
Surgery
Treatment Outcome
Liver
Ferritins
Female
Plasma iron
business
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 16000609 and 09024441
- Volume :
- 82
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- European Journal of Haematology
- Accession number :
- edsair.doi.dedup.....30746b429ae7232d973ba420a01c8832