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SNX29, a new susceptibility gene shared with major mental disorders in Han Chinese population
- Source :
- The World Journal of Biological Psychiatry. 22:526-534
- Publication Year :
- 2020
- Publisher :
- Informa UK Limited, 2020.
-
Abstract
- Environmental and genetic factors play important roles in the development of schizophrenia (SCZ), bipolar disorder (BPD) or major depressive disorder (MDD). Some risk loci are identified with shared genetic effects on major psychiatric disorders. To investigate whetherWe focussed on 11 single-nucleotide polymorphisms (SNPs) harbouringWe found that rs3743592 was significantly associated with MDD and rs6498263 with BPD in both allele and genotype distributions. Before correction, rs3743592 showed allelic and genotypic significance with SCZ, rs6498263 showed allelic significance with SCZ. WGCNA identified top 10 modules of co-expressed genes. Gene Ontology (GO) and pathway analysis were used to examine the functions of SNX29, which revealed that SNX29 was involved in the regulation of a number of biological processes, such as TGF-beta, ErbB, and Wnt signalling pathway, etc.Our results supported common risk factors in
- Subjects :
- China
medicine.medical_specialty
Han chinese
Bipolar Disorder
Susceptibility gene
Polymorphism, Single Nucleotide
behavioral disciplines and activities
03 medical and health sciences
0302 clinical medicine
Asian People
mental disorders
medicine
Humans
Genetic Predisposition to Disease
Bipolar disorder
Psychiatry
Sorting Nexins
Biological Psychiatry
Depressive Disorder, Major
business.industry
Mental Disorders
medicine.disease
030227 psychiatry
Psychiatry and Mental health
Schizophrenia
Case-Control Studies
Major depressive disorder
business
Subjects
Details
- ISSN :
- 18141412 and 15622975
- Volume :
- 22
- Database :
- OpenAIRE
- Journal :
- The World Journal of Biological Psychiatry
- Accession number :
- edsair.doi.dedup.....306f73a6b495caf9a62c135071ba9be5