Back to Search
Start Over
Intranetwork and internetwork connectivity in patients with Alzheimer disease and the association with cerebrospinal fluid biomarker levels
- Source :
- Journal of Psychiatry & Neuroscience. 42:366-377
- Publication Year :
- 2017
- Publisher :
- CMA Joule Inc., 2017.
-
Abstract
- Background: In the last decade, many studies have reported abnormal connectivity within the default mode network (DMN) in patients with Alzheimer disease. Few studies, however, have investigated other networks and their association with pathophysiological proteins obtained from cerebrospinal fluid (CSF). Methods: We performed 3 T imaging in patients with mild Alzheimer disease, patients with amnestic mild cognitive impairment (aMCI) and healthy controls, and we collected CSF samples from the patients with aMCI and mild Alzheimer disease. We analyzed 57 regions from 8 networks. Additionally, we performed correlation tests to investigate possible associations between the networks’ functional connectivity and the protein levels obtained from the CSF of patients with aMCI and Alzheimer disease. Results: Our sample included 41 patients with Alzheimer disease, 35 with aMCI and 48 controls. We found that the main connectivity abnormalities in those with Alzheimer disease occurred between the DMN and task-positive networks: these patients presented not only a decreased anticorrelation between some regions, but also an inversion of the correlation signal (positive correlation instead of anti-correlation). Those with aMCI did not present statistically different connectivity from patients with Alzheimer disease or controls. Abnormal levels of CSF proteins were associated with functional disconnectivity between several regions in both the aMCI and mild Alzheimer disease groups, extending well beyond the DMN or temporal areas. Limitations: The presented data are cross-sectional in nature, and our findings are dependent on the choice of seed regions used. Conclusion: We found that the main functional connectivity abnormalities occur between the DMN and task-positive networks and that the pathological levels of CSF biomarkers correlate with functional connectivity disruption in patients with Alzheimer disease.
- Subjects :
- Male
0301 basic medicine
Oncology
medicine.medical_specialty
Cross-sectional study
Rest
Neuropsychological Tests
Brain mapping
03 medical and health sciences
0302 clinical medicine
Cerebrospinal fluid
Alzheimer Disease
Internal medicine
Neural Pathways
mental disorders
medicine
Humans
Cognitive Dysfunction
Pharmacology (medical)
Pathological
Biological Psychiatry
Default mode network
Aged
Brain Mapping
medicine.diagnostic_test
business.industry
Brain
Magnetic resonance imaging
medicine.disease
Magnetic Resonance Imaging
Pathophysiology
Psychiatry and Mental health
Cross-Sectional Studies
030104 developmental biology
Female
Alzheimer's disease
business
Biomarkers
030217 neurology & neurosurgery
Research Paper
Subjects
Details
- ISSN :
- 11804882
- Volume :
- 42
- Database :
- OpenAIRE
- Journal :
- Journal of Psychiatry & Neuroscience
- Accession number :
- edsair.doi.dedup.....306942bc623b2d01d9f0424db16360c6