Back to Search
Start Over
Efficacy of Cinnamon as an Adjuvant in Reducing the Glycemic Biomarkers of Type 2 Diabetes Mellitus: A Three-Month, Randomized, Triple-Blind, Placebo-Controlled Clinical Trial
- Source :
- Journal of the American Nutrition Association. 41(3)
- Publication Year :
- 2021
-
Abstract
- The major aim of this randomized, placebo-controlled, triple-blind clinical trial was to evaluate the efficacy of cinnamon as an adjuvant treatment in reducing glycemic levels in people with type 2 diabetes, compared to a placebo. The study was conducted between August and December 2019, with 160 people with type 2 diabetes, in five Primary Health Units, in Parnaíba, Brazil. Inclusion criteria were: persons of both genders using oral antidiabetic agents, with glycated hemoglobin ≥ 6.0%, and between 18 and 80 years of age. The primary outcome was change in glycated hemoglobin levels after 90 days of intervention. Other biomarkers evaluated were fasting blood glucose, insulin level, and HOMA-IR index. Participants were divided equally into two groups of 80 individuals each, and were given 3 g capsules of either cinnamon or placebo to be taken in combination with their usual oral antidiabetic agents. After 90 days, participants in the cinnamon group had statistically significant reductions of 0.2% of glycated hemoglobin and 0.55 mmol/L of fasting venous glucose, when compared with the placebo group. Cinnamon reduced the glycemic measures of persons with type 2 diabetes, albeit with modest reductions. TRIAL: RBR-2KKB6D.
- Subjects :
- 0301 basic medicine
Blood Glucose
Male
medicine.medical_specialty
Cinnamomum zeylanicum
medicine.medical_treatment
030209 endocrinology & metabolism
Placebo
03 medical and health sciences
0302 clinical medicine
Adjuvants, Immunologic
Internal medicine
Medicine
Humans
Hypoglycemic Agents
Glycemic
Adjuvants, Pharmaceutic
Glycated Hemoglobin
030109 nutrition & dietetics
business.industry
Type 2 Diabetes Mellitus
Clinical trial
Diabetes Mellitus, Type 2
Female
business
Adjuvant
Biomarkers
Subjects
Details
- ISSN :
- 2769707X
- Volume :
- 41
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Journal of the American Nutrition Association
- Accession number :
- edsair.doi.dedup.....305f8e9a82ee6b91ae419771e5b91d4e