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A new antioxidant isobenzofuranone derivative from the algicolous marine fungus Epicoccum sp
- Source :
- Planta medica. 69(9)
- Publication Year :
- 2003
-
Abstract
- The fungus Epicoccum sp., was isolated from the marine brown alga Fucus vesiculosus. After cultivation the fungus was investigated for its secondary metabolite content, and found to contain the new natural product 4,5,6-trihydroxy-7-methylphthalide (1, epicoccone), together with 5-(acetoxymethyl)-furan-2-carboxylic acid (2), furan-2-carboxylic acid (3), 5-(hydroxymethyl)-furan-2-carboxylic acid (4), (-)-(3 R,4 S)-4-hydroxymellein (5), and (-)-(3 R)-5-hydroxymellein (6). The structures of all compounds were determined by interpretation of their spectroscopic data (1D and 2D NMR, MS, UV, optical rotation and IR). Each isolate was tested for its antioxidative properties. Compound 1 was found to be potently active, showing 95 % DPPH radical scavenging effects at 25 microg/mL. Compound 1 also inhibited the peroxidation of linolenic acid in the TBARS assay (62 % inhibition at 37 microg/mL).
- Subjects :
- Antioxidant
Magnetic Resonance Spectroscopy
DPPH
Linolenic acid
Stereochemistry
medicine.medical_treatment
Pharmaceutical Science
Fucus vesiculosus
Secondary metabolite
Antioxidants
Gas Chromatography-Mass Spectrometry
Analytical Chemistry
chemistry.chemical_compound
Picrates
Drug Discovery
Botany
medicine
TBARS
Humans
Hydroxymethyl
Seawater
Chromatography, High Pressure Liquid
Pharmacology
Natural product
biology
Plant Extracts
Organic Chemistry
Biphenyl Compounds
Fungi
alpha-Linolenic Acid
biology.organism_classification
Complementary and alternative medicine
chemistry
Molecular Medicine
medicine.drug
Phytotherapy
Subjects
Details
- ISSN :
- 00320943
- Volume :
- 69
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- Planta medica
- Accession number :
- edsair.doi.dedup.....30528ba129728a0c4eac5153d7c1196f