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Biological markers for anxiety disorders, OCD and PTSD: A consensus statement. Part II: Neurochemistry, neurophysiology and neurocognition
- Source :
- Bandelow, B, Baldwin, D, Abelli, M, Bolea-Alamanac, B, Bourin, M, Chamberlain, S R, Cinosi, E, Davies, S, Domschke, K, Fineberg, N, Grünblatt, E, Jarema, M, Kim, Y-K, Maron, E, Masdrakis, V, Mikova, O, Nutt, D, Pallanti, S, Pini, S, Ströhle, A, Thibaut, F, Vaghi, M M, Won, E, Wedekind, D, Wichniak, A, Woolley, J, Zwanzger, P & Riederer, P 2017, ' Biological markers for anxiety disorders, OCD and PTSD: A consensus statement. Part II : Neurochemistry, neurophysiology and neurocognition ', World Journal of Biological Psychiatry, vol. 18, no. 3, pp. 162-214 . https://doi.org/10.1080/15622975.2016.1190867
- Publication Year :
- 2016
-
Abstract
- OBJECTIVE: Biomarkers are defined as anatomical, biochemical or physiological traits that are specific to certain disorders or syndromes. The objective of this paper is to summarise the current knowledge of biomarkers for anxiety disorders, obsessive-compulsive disorder (OCD) and posttraumatic stress disorder (PTSD).METHODS: Findings in biomarker research were reviewed by a task force of international experts in the field, consisting of members of the World Federation of Societies for Biological Psychiatry Task Force on Biological Markers and of the European College of Neuropsychopharmacology Anxiety Disorders Research Network.RESULTS: The present article (Part II) summarises findings on potential biomarkers in neurochemistry (neurotransmitters such as serotonin, norepinephrine, dopamine or GABA, neuropeptides such as cholecystokinin, neurokinins, atrial natriuretic peptide, or oxytocin, the HPA axis, neurotrophic factors such as NGF and BDNF, immunology and CO2 hypersensitivity), neurophysiology (EEG, heart rate variability) and neurocognition. The accompanying paper (Part I) focuses on neuroimaging and genetics.CONCLUSIONS: Although at present, none of the putative biomarkers is sufficient and specific as a diagnostic tool, an abundance of high quality research has accumulated that should improve our understanding of the neurobiological causes of anxiety disorders, OCD and PTSD.
- Subjects :
- Obsessive-Compulsive Disorder
Review
Stress Disorders, Post-Traumatic
2738 Psychiatry and Mental Health
0302 clinical medicine
10064 Neuroscience Center Zurich
Societies, Medical
Stress Disorders
Randomized Controlled Trials as Topic
neuroimaging
neurobiology
10058 Department of Child and Adolescent Psychiatry
Anxiety Disorders
3. Good health
Neuropsychopharmacology
Psychiatry and Mental Health
10076 Center for Integrative Human Physiology
Biomarker (medicine)
Anxiety
medicine.symptom
Biological psychiatry
Psychology
Anxiety disorders
genetic
neurochemistry
review
Advisory Committees
Biological Psychiatry
Consensus
Humans
Biomarkers
2803 Biological Psychiatry
Clinical psychology
medicine.drug
610 Medicine & health
Article
03 medical and health sciences
Norepinephrine
Neuroimaging
Medical
medicine
Journal Article
Neurochemistry
030227 psychiatry
Post-Traumatic
Societies
Neurocognitive
Neuroscience
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Bandelow, B, Baldwin, D, Abelli, M, Bolea-Alamanac, B, Bourin, M, Chamberlain, S R, Cinosi, E, Davies, S, Domschke, K, Fineberg, N, Grünblatt, E, Jarema, M, Kim, Y-K, Maron, E, Masdrakis, V, Mikova, O, Nutt, D, Pallanti, S, Pini, S, Ströhle, A, Thibaut, F, Vaghi, M M, Won, E, Wedekind, D, Wichniak, A, Woolley, J, Zwanzger, P & Riederer, P 2017, ' Biological markers for anxiety disorders, OCD and PTSD: A consensus statement. Part II : Neurochemistry, neurophysiology and neurocognition ', World Journal of Biological Psychiatry, vol. 18, no. 3, pp. 162-214 . https://doi.org/10.1080/15622975.2016.1190867
- Accession number :
- edsair.doi.dedup.....30456800c24c8918537177ff513f2ac6