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Predictive Value of Underweight Status for Patients With Peripheral Artery Disease With Claudication
- Source :
- Angiology. 69(6)
- Publication Year :
- 2017
-
Abstract
- We evaluated whether underweight status is associated with poor prognosis in patients with peripheral artery disease (PAD) with claudication, excluding critical limb ischemia. We identified 441 claudicants hospitalized for cardiovascular disease between 2005 and 2012. Patients were divided into 4 groups according to body mass index (BMI): an underweight group (BMI < 18.5 kg/m2; n = 48), a normal group (BMI = 18.5-25.0 kg/m2; n = 286), an overweight group (BMI = 25.0-30.0 kg/m2; n = 92), and an obese group (BMI ≥ 30.0 kg/m2; n = 15). The mean follow-up period was 3.5 ± 1.9 years. The underweight group had significantly lower levels of hemoglobin, albumin, estimated glomerular filtration rate, triglycerides, and hemoglobin A1c; higher levels of C-reactive protein and B-type natriuretic peptide; and a higher prevalence of hemodialysis. The incidence of all-cause death and cardiovascular death was significantly higher in the underweight group (underweight vs normal, 77.1% vs 33.0%; P < .001 and 43.3% vs 14.4%; P < .001, respectively). In a multivariate Cox analysis, underweight status was an independent predictor of all-cause death (hazard ratio, 2.53; 95% confidence interval, 1.58-4.18; P < .001). Therefore, promoting weight gain, as well as managing cardiovascular disease, may be important for underweight patients with PAD.
- Subjects :
- Adult
Male
medicine.medical_specialty
030204 cardiovascular system & hematology
Overweight
Gastroenterology
Body Mass Index
03 medical and health sciences
Peripheral Arterial Disease
0302 clinical medicine
Thinness
Predictive Value of Tests
Risk Factors
Internal medicine
medicine
Humans
030212 general & internal medicine
Aged
Proportional Hazards Models
Aged, 80 and over
business.industry
Hazard ratio
nutritional and metabolic diseases
Critical limb ischemia
Intermittent Claudication
Middle Aged
Prognosis
Intermittent claudication
Surgery
Female
medicine.symptom
Underweight
Cardiology and Cardiovascular Medicine
business
Claudication
Weight gain
Body mass index
Subjects
Details
- ISSN :
- 19401574
- Volume :
- 69
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Angiology
- Accession number :
- edsair.doi.dedup.....3044502fd8a49f56736cef1b09581451