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Prevalence, risk factors, and epidemiology of methicillin-resistantStaphylococcus aureus carried by adults over 60 years of age
- Source :
- European Journal of Clinical Microbiology & Infectious Diseases. 34:593-600
- Publication Year :
- 2014
- Publisher :
- Springer Science and Business Media LLC, 2014.
-
Abstract
- The epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) in the community in Portugal is not completely understood. To evaluate S. aureus and MRSA carriage among the elderly, we conducted a large cross-sectional study between April 2010 and December 2012. A total of 3,361 adults over 60 years of age were screened for S. aureus nasopharyngeal and oropharyngeal carriage. MRSA were characterized by staphylococcal cassette chromosome mec (SCCmec) typing, spa typing, multilocus sequence typing (MLST), and tested for the presence of Panton-Valentine leukocidin (PVL). Risk factors for MRSA carriage were identified by multiple logistic regression analysis. The prevalence of S. aureus and MRSA carriage among the elderly was 20.1 % and 1.8 %, respectively. The risk of being an MRSA carrier was higher among the elderly living in retirement homes [odds ratio (OR) = 2.90, 95 % confidence interval (CI): 1.48-5.48] and those that had been hospitalized in the previous year (OR = 2.64, 95 % CI: 1.47-4.58). Among the 62 MRSA isolates, 64.5 % were multidrug-resistant and none carried PVL. Most MRSA (82.3 %) were related to three hospital-associated (HA-MRSA) clones disseminated in Portugal: ST105-II (New York/Japan clone; 43.5 %), ST5-IVc (Pediatric clone; 19.4 %), and ST22-IVh (EMRSA-15 clone; 19.4 %). The New York/Japan and Pediatric clones were significantly associated with carriers living in retirement homes, while the EMRSA-15 clone was associated with carriers that had been hospitalized. We conclude that the elderly population in Portugal is essentially free of MRSA. Given the current European societal challenges for a healthy active aging, these results are of importance to healthcare professionals and public authorities to decide on strategies to promote health in this age group.
- Subjects :
- Male
Methicillin-Resistant Staphylococcus aureus
Microbiology (medical)
medicine.medical_specialty
Pediatrics
Genotype
Cross-sectional study
Bacterial Toxins
Exotoxins
Oropharynx
Staphylococcal infections
medicine.disease_cause
Leukocidins
Risk Factors
Nasopharynx
Epidemiology
Prevalence
Cluster Analysis
Humans
Medicine
Aged
Aged, 80 and over
Portugal
business.industry
SCCmec
General Medicine
Odds ratio
Middle Aged
Staphylococcal Infections
biochemical phenomena, metabolism, and nutrition
bacterial infections and mycoses
medicine.disease
Methicillin-resistant Staphylococcus aureus
Molecular Typing
Cross-Sectional Studies
Infectious Diseases
Carriage
Carrier State
Multilocus sequence typing
business
Subjects
Details
- ISSN :
- 14354373 and 09349723
- Volume :
- 34
- Database :
- OpenAIRE
- Journal :
- European Journal of Clinical Microbiology & Infectious Diseases
- Accession number :
- edsair.doi.dedup.....3043b9e5f2515facb4e6889e02b59a65