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Intracranial Management of Perineural Spread in the Trigeminal Nerve
- Source :
- Journal of neurological surgery. Part B, Skull base. 77(2)
- Publication Year :
- 2016
-
Abstract
- Since the mid-1960s surgeons have attempted to cure intracranial perineural spread (PNS) of cutaneous malignancies. Untreated patients with trigeminal PNS die from brainstem invasion and leptomeningeal disease. It was understood that resection with clear margins was potentially curative, but early surgical attempts were unsuccessful. The prevailing wisdom considered that this surgery failed to improve the results achieved with radiation therapy alone and was associated with high morbidity. However, with improved imaging, surgical equipment, and better understanding of cavernous sinus (CS) anatomy and access, contemporary surgeons can improve outcomes for this disease. The aim of this paper is to describe a technique to access the interdural compartment of the CS and treat PNS of cutaneous squamous cell carcinoma (cSCC) in the intracranial trigeminal nerve and ganglion. It is based on the experience of the Queensland Skull Base Unit, Australia in managing PNS of cutaneous squamous cell carcinoma of the head and neck (cSCCHN).
- Subjects :
- Trigeminal nerve
medicine.medical_specialty
business.industry
medicine.medical_treatment
Article
Ganglion
Surgery
Radiation therapy
03 medical and health sciences
High morbidity
Skull
0302 clinical medicine
medicine.anatomical_structure
030220 oncology & carcinogenesis
Cavernous sinus
Perineural spread
Surgical equipment
Medicine
Neurology (clinical)
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 21936331
- Volume :
- 77
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Journal of neurological surgery. Part B, Skull base
- Accession number :
- edsair.doi.dedup.....303f1168ce23428c2b846c501bcb9ada