Back to Search
Start Over
Infiltrating and peripheral immune cell analysis in advanced gastric cancer according to the Lauren classification and its prognostic significance
- Source :
- Gastric Cancer, Gastric Cancer, Springer Verlag (Germany), 2019, ⟨10.1007/s10120-019-00983-3⟩, Gastric Cancer, 2019, ⟨10.1007/s10120-019-00983-3⟩
- Publication Year :
- 2019
- Publisher :
- HAL CCSD, 2019.
-
Abstract
- The correlation between immune cells and the Lauren classification subtypes and their prognostic impact in advanced gastric cancer (AGC) are unknown. Circulating natural killer (NK) cells, CD4+ and CD8+ T cells, regulatory T cells (Tregs) and myeloid-derived suppressor cells (MDSCs) were quantified in peripheral blood mononuclear cells (PBMCs) from 67 patients with untreated AGC enrolled in the PRODIGE 17-ACCORD 20 trial. CD56+ cells (NK), CD8+, and FoxP3+ (Treg) tumor-infiltrating lymphocytes (TILs) were assessed in tumor samples. Circulating NK and Treg proportions were significantly lower in patients with diffuse/mixed-type AGC (n = 27) than those with intestinal type (n = 40; median 6.3% vs 11.5%; p = 0.02 and median 3.3% vs 5.2%; p = 0.03, respectively). Proportions of circulating MDSC, CD4+ and CD8+ T cells were not associated with one pathological type. Among tumor-infiltrating cells, CD8+ T cells, but not NK or FoxP3+ cells, were significantly lower in diffuse/mixed-type AGC (median 21 vs 59 cells/field; p = 0.009). Patients with high circulating NK cell counts (> 17%) had a better overall survival than those with 31 cells/field) had significantly longer overall survival (HR 0.44; 95% CI [0.21–0.92]; p = 0.02). The prognostic value of CD8+ TILs was maintained after adjustment for confounding factors, including the Lauren classification (HR = 0.42; 95% CI [0.18–0.96]; p = 0.039). Diffuse/mixed-type AGC has lower rates of CD8+ TILs and circulating NK cells and Tregs than the intestinal type. This “cold tumor” phenotype may be associated with a worse outcome.
- Subjects :
- Adult
Male
Cancer Research
medicine.medical_specialty
Cell
[SDV.CAN]Life Sciences [q-bio]/Cancer
Kaplan-Meier Estimate
Peripheral blood mononuclear cell
Gastroenterology
03 medical and health sciences
Lymphocytes, Tumor-Infiltrating
0302 clinical medicine
Immune system
Stomach Neoplasms
Surgical oncology
Internal medicine
medicine
Humans
Pathological
ComputingMilieux_MISCELLANEOUS
Aged
Aged, 80 and over
business.industry
FOXP3
General Medicine
Middle Aged
Prognosis
3. Good health
Killer Cells, Natural
medicine.anatomical_structure
Oncology
030220 oncology & carcinogenesis
Leukocytes, Mononuclear
Biomarker (medicine)
Female
030211 gastroenterology & hepatology
business
CD8
Subjects
Details
- Language :
- English
- ISSN :
- 14363291
- Database :
- OpenAIRE
- Journal :
- Gastric Cancer, Gastric Cancer, Springer Verlag (Germany), 2019, ⟨10.1007/s10120-019-00983-3⟩, Gastric Cancer, 2019, ⟨10.1007/s10120-019-00983-3⟩
- Accession number :
- edsair.doi.dedup.....303d9ff9ef7a1522982974c9cc1523c1