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Rice Intake, Arsenic Exposure, and Subclinical Cardiovascular Disease Among US Adults in MESA
- Source :
- Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
- Publication Year :
- 2020
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2020.
-
Abstract
- Background Arsenic‐related cardiovascular effects at exposure levels below the US Environmental Protection Agency's standard of 10 μg/L are unclear. For these populations, food, especially rice, is a major source of exposure. We investigated associations of rice intake, a marker of arsenic exposure, with subclinical cardiovascular disease (CVD) markers in a multiethnic population. Methods and Results Between 2000 and 2002, MESA (Multi‐Ethnic Study of Atherosclerosis) enrolled 6814 adults without clinical CVD . We included 5050 participants with baseline data on rice intake and markers of 3 CVD domains: inflammation (hsCRP [high‐sensitivity C‐reactive protein], interleukin‐6, and fibrinogen), vascular function (aortic distensibility, carotid distensibility, and brachial flow‐mediated dilation), and subclinical atherosclerosis at 3 vascular sites (carotid intima‐media thickness, coronary artery calcification, and ankle‐brachial index). We also evaluated endothelial‐related biomarkers previously associated with arsenic. Rice intake was assessed by food frequency questionnaire. Urinary arsenic was measured in 310 participants. A total of 13% of participants consumed ≥1 serving of rice/day. Compared with individuals consuming CVD risk factor adjustment (eg, geometric mean ratio [95% CI ] for hs CRP , 0.98 [0.86–1.11]; aortic distensibility, 0.99 [0.91–1.07]; and carotid intima‐media thickness, 0.98 [0.91–1.06]). Associations with urinary arsenic were similar to those for rice intake. Conclusions Rice intake was not associated with subclinical CVD markers in a multiethnic US population. Research using urinary arsenic is needed to assess potential CVD effects of low‐level arsenic exposure. Understanding the role of low‐level arsenic as it relates to subclinical CVD may contribute to CVD prevention and control.
- Subjects :
- Adult
Male
Epidemiology
Rice intake
chemistry.chemical_element
Disease
030204 cardiovascular system & hematology
010501 environmental sciences
01 natural sciences
White People
Cohort Studies
03 medical and health sciences
0302 clinical medicine
cardiovascular disease
Risk Factors
Surveys and Questionnaires
Environmental health
Ethnicity
Humans
Medicine
cardiovascular diseases
ARSENIC EXPOSURE
Arsenic
Original Research
Diet and Nutrition
0105 earth and related environmental sciences
Subclinical infection
2. Zero hunger
business.industry
rice
arsenic
Oryza
Diet
3. Good health
chemistry
inflammation
Cardiovascular Diseases
Female
Cardiology and Cardiovascular Medicine
business
Biomarkers
Subjects
Details
- ISSN :
- 20479980
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- Journal of the American Heart Association
- Accession number :
- edsair.doi.dedup.....3026b784b317a5162ee823f02183b046