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The diterpenoid adenanthin upregulates the expression of natural killer group 2D receptor ligands in hepatocellular carcinoma cells
- Source :
- Molecular and Cellular Probes. 59:101759
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- Objective The natural killer (NK) group 2D (NKG2D) receptor plays a crucial role in NK cell-mediated anti-tumor immunity. NKG2D anti-proliferative effect is mediated by direct interactions of the receptor with its ligands that may be considered as a potential target for NK-based immunotherapeutic strategy in cancer cells. Methods Here we report that a natural product adenanthin significantly promotes NKG2D ligands expression in hepatoma cells. The effect was determined using flow cytometry analysis. The activity of NK cell was evaluated by measuring its degranulation activity and cytotoxicity. Results Our data indicates that the induction of NKG2D ligand binding to liver cancer cell surface receptors greatly improves the killing activity of NK cells against the cancer cells. Conclusions This is the first report of a new mechanism anti-cancer effects of adenanthin mediated by an indirect activation of NK cells. Our data suggests that adenanthin may be used to sensitize NK cells in tumor immunotherapy.
- Subjects :
- Carcinoma, Hepatocellular
medicine.diagnostic_test
medicine.medical_treatment
Liver Neoplasms
Cell
Degranulation
chemical and pharmacologic phenomena
Cell Biology
Immunotherapy
Biology
Ligands
NKG2D
Flow cytometry
Killer Cells, Natural
medicine.anatomical_structure
Cell surface receptor
Cell Line, Tumor
Cancer cell
medicine
Cancer research
Humans
Diterpenes, Kaurane
Receptor
Molecular Biology
Subjects
Details
- ISSN :
- 08908508
- Volume :
- 59
- Database :
- OpenAIRE
- Journal :
- Molecular and Cellular Probes
- Accession number :
- edsair.doi.dedup.....3022eb9102f28d5fc7d205cfb5aec9d3