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Histopathological Analysis of 226 Patients With Rosacea According to Rosacea Subtype and Severity
- Source :
- The American Journal of dermatopathology. 38(5)
- Publication Year :
- 2015
-
Abstract
- BACKGROUND The histopathological features of rosacea have not been described in detail. OBJECTIVE To evaluate the histopathological features of rosacea according to clinical characteristics such as subtype and severity. METHODS We retrospectively analyzed histopathological findings in 226 patients with rosacea, which included 52 patients with the erythematotelangiectatic rosacea (ETR) and 174 patients with the papulopustular rosacea (PPR) subtype. The frequency of each histopathological finding was compared between subtypes. Histopathological features were also compared according to the severity, through subgroup analysis within each subtype group. RESULTS Perivascular and perifollicular lymphohistiocytic infiltration were common dermal findings in both subtype groups, but the intensity of dermal inflammatory infiltration was higher in PPR than in ETR. Follicular spongiosis and exocytosis of inflammatory cells into hair follicles were noted in both subtypes; but these findings were significantly more common in the PPR subtype. Vascular changes (telangiectasia and proliferation) and solar elastosis were common histopathological findings in both subtypes, with no difference in frequency between subtype groups. Demodex mites were identified in about 40% of patients, and the frequency of demodex mites did not differ between subtype groups. The intensity of perifollicular inflammation and the presence of follicular inflammatory reactions were dependent on the severity of rosacea in both subtype groups. CONCLUSIONS The intensity of inflammatory reactions, especially perifollicular infiltration, was higher in PPR patients than in ETR patients. Rosacea has a spectrum of histopathological features that are related to clinical progression between rosacea subtypes.
- Subjects :
- 0301 basic medicine
Adult
Male
Pathology
medicine.medical_specialty
Mite Infestations
Adolescent
Databases, Factual
Biopsy
Dermatology
Severity of Illness Index
Pathology and Forensic Medicine
030207 dermatology & venereal diseases
03 medical and health sciences
Young Adult
0302 clinical medicine
Follicular phase
Severity of illness
medicine
Animals
Humans
Young adult
Telangiectasia
Child
Aged
Retrospective Studies
Skin
Aged, 80 and over
Mites
integumentary system
medicine.diagnostic_test
business.industry
General Medicine
Middle Aged
medicine.disease
030104 developmental biology
Rosacea
Disease Progression
Female
medicine.symptom
business
Infiltration (medical)
Spongiosis
Subjects
Details
- ISSN :
- 15330311
- Volume :
- 38
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- The American Journal of dermatopathology
- Accession number :
- edsair.doi.dedup.....300f7d1f6fe62372359e4eb2ac805923