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Cu2+-doping of polyanionic brushes: A facile route to prepare implant coatings with both antifouling and antibacterial properties
- Source :
- European polymer journal, 134:109845. Elsevier
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- Infections strongly reduce the success rate of implant-related medical procedures. The incorporation of anti-bacterial implant coatings can reduce the chance of infection. However, most of these coatings do not repel bacteria, such that dead bacteria stay on the surface and the performance of these coatings degrades. Ideally, implant coatings should repel bacteria and inhibit bacterial growth in the event of attachment. Unfortunately, the preparation of such coatings often involve complex and expensive synthesis steps, or rely on antibiotics. In this article, we present a simple, inexpensive and robust technique to prepare implant coatings without the use of antibiotics. Our coatings have both anti-fouling and anti-bacterial properties, such that bacteria do not stick to the implant surface and are killed when they come into contact. The coating is composed of poly(3-sulfopropyl methacrylate potassium salt) (Cu@PSPMAK) polymer brushes doped with copper ions (Cu2+). The Cu2+ in the Cu@PSPMAK coating enables an excellent antibacterial efficiency against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli), while the PSPMAK polymer brushes in the coating effectively repel the (dead) bacteria. We show using both in vitro and in vivo tests that the Cu@PSPMAK coating is indeed very effective in avoiding implant-related infections. Moreover, the tests show that the Cu@PSPMAK coating is also biocompatible and accepted within the body. All this makes the Cu@PSPMAK coating an ideal solution for combatting bacterial infections at implants.
- Subjects :
- Polymer brush
Materials science
Polymers and Plastics
Implant coatings
General Physics and Astronomy
02 engineering and technology
Bacterial growth
engineering.material
010402 general chemistry
Methacrylate
01 natural sciences
Biofouling
Coating
Bacterial infections
Materials Chemistry
chemistry.chemical_classification
biology
Organic Chemistry
22/2 OA procedure
Anti-fouling
Polymer
021001 nanoscience & nanotechnology
biology.organism_classification
0104 chemical sciences
chemistry
Chemical engineering
engineering
Implant
0210 nano-technology
Anti-bacterial
Bacteria
Subjects
Details
- ISSN :
- 00143057
- Volume :
- 134
- Database :
- OpenAIRE
- Journal :
- European Polymer Journal
- Accession number :
- edsair.doi.dedup.....300849d6500e9e9667bcac2bcd448c59