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The disc damage likelihood scale: Diagnostic accuracy and correlations with cup-to-disc ratio, structural tests and standard automated perimetry
- Source :
- PLoS ONE, Vol 12, Iss 7, p e0181428 (2017), Repositório Institucional da UNIFESP, Universidade Federal de São Paulo (UNIFESP), instacron:UNIFESP, PLoS ONE
- Publication Year :
- 2017
- Publisher :
- Public Library of Science (PLoS), 2017.
-
Abstract
- CAPES/Ministry of Education of Brazil CNPq/Ministry of Science and Technology of Brazil Our objective was to compare the diagnostic accuracies of and to determine the correlations between the disc damage likelihood scale (DDLS) and anatomical and functional tests used for glaucoma detection. A total of 54 healthy subjects (54 eyes) and 47 primary open-angle glaucoma patients (47 eyes) were included in this cross-sectional observational study. DDLS scores and cup-to-disc (C/D) ratios were evaluated. Subjects underwent standard automated perimetry (SAP), optic disc and retinal nerve fiber layer (RNFL) imaging with time and spectral-domain optical coherence tomography (TD and SD-OCT), Heidelberg Retina Tomograph (HRT II), and scanning laser polarimetry (GDx-VCC). Areas under the receiver operating characteristic curves (AROCs) for DDLS and diagnostic tests parameters were calculated. DDLS correlations (Spearman's rank) among these parameters were analyzed. Fifty-four eyes were healthy and 47 had glaucoma, including 16 preperimetric glaucoma. DDLS, vertical and horizontal C/D ratios had the largest AROCs (0.92, 0.94 and 0.91, respectively). DDLS diagnostic accuracy was better than the accuracies of HRT II parameters, TD and SD-OCT RNFL thicknesses, and SAP mean deviation (MD) index. There were no significant differences between the accuracies of the DDLS and the C/D ratios, TD-OCT vertical (0.89) and horizontal (0.86) C/D ratios, TD-OCT C/D area ratio (0.89), and GDx-VCC NFI (0.81). DDLS showed significant strong correlations with vertical (r = 0.79) and horizontal (0.74) C/D ratios, and with the parameters vertical C/D ratio and C/D area ratio from HRT II (both 0.77) and TD-OCT (0.75 and 0.72, respectively). DDLS had significant moderate correlations with most of the other structural measurements and SAP MD. The optic disc clinical evaluation with DDLS system and C/D ratio demonstrated excellent accuracy in distinguishing glaucomatous from healthy eyes. DDLS had moderate to strong correlations with most structural and functional parameters. These findings stress the importance of optic disc clinical examination to detect glaucoma in a clinical scenario. Univ Fed Sao Paulo, Escola Paulista Med, Dept Ophthalmol & Visual Sci, Glaucoma Div, Sao Paulo, SP, Brazil Univ Fed Sao Paulo, Escola Paulista Med, Dept Ophthalmol & Visual Sci, Glaucoma Div, Sao Paulo, SP, Brazil CAPES CNPq Web of Science
- Subjects :
- Male
Eye Diseases
genetic structures
Optic disk
Nerve fiber layer
Glaucoma
Scanning laser polarimetry
lcsh:Medicine
Cup-to-disc ratio
Severity of Illness Index
Diagnostic Radiology
0302 clinical medicine
Nerve Fibers
Animal Cells
Medicine and Health Sciences
lcsh:Science
Tomography
Mathematics
Neurons
Multidisciplinary
medicine.diagnostic_test
Radiology and Imaging
Middle Aged
Prognosis
medicine.anatomical_structure
Optical Equipment
Scanning Laser Polarimetry
Area Under Curve
Engineering and Technology
Female
Anatomy
Cellular Types
Glaucoma, Open-Angle
Tomography, Optical Coherence
Optic disc
Research Article
medicine.medical_specialty
Imaging Techniques
Ocular Anatomy
Optic Disk
Equipment
Research and Analysis Methods
Optic Disc
Retina
03 medical and health sciences
Optical coherence tomography
Ocular System
Diagnostic Medicine
Ophthalmology
medicine
Humans
Aged
Receiver operating characteristic
Lasers
lcsh:R
Biology and Life Sciences
Cell Biology
medicine.disease
eye diseases
Cross-Sectional Studies
ROC Curve
Cellular Neuroscience
030221 ophthalmology & optometry
Eyes
Visual Field Tests
lcsh:Q
sense organs
Head
030217 neurology & neurosurgery
Neuroscience
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 12
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....3005e9d5002a154488eb010ca4dc5811