Back to Search
Start Over
Long-term outcomes of basic fibroblast growth factor treatments in patients with vocal fold scarring, aged vocal fold, and sulcus vocalis
- Source :
- Auris Nasus Larynx. 48:949-955
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- Objective Fibrotic changes in the vocal fold mucosa have been observed in patients with vocal fold scarring, aged vocal fold, and sulcus vocalis, which often lead to severe voice disorders. Previous research suggests that the basic fibroblast growth factor (b FGF) improves variations in vocal fold properties [1 , 2] . Although clinical studies on b FGF treatments have been conducted [3 , 4 , 5] , these studies only demonstrated the efficacy of this drug over a short period. The present study is the first to investigate the long-term efficacy of b FGF treatment. Methods b FGF injections were performed in six patients from January of 2016 to December of 2017 at our institution. Patient follow-up continued for at least two years after the last injection. Three patients had vocal fold scarring, two had aged vocal fold atrophy, and one patient had sulcus vocalis. Each vocal fold was injected with 10 µg of b FGF four times. Voice and stroboscopic examinations were performed after surgery (at one month, three months, six months, one year, two years). Fundamental frequency, maximum phonation time (MPT), mean flow rate (MFR), amplitude perturbation quotient (APQ), pitch perturbation quotient (PPQ), and noise-to-harmonic ratio (NHR), and voice handicap index-10 (VHI-10) were examined and compared statistically between the pretreatment time and at each posttreatment time point. Results The speaking F0 had an obvious decreasing tendency, with significant differences suggesting the increase in volume in the vocal folds. Aerodynamic parameters also showed small improvements. The most remarkable improvement was observed in the acoustic parameters, indicating that the treatment could improve the vocal fold to make vibrations symmetrically and regularly for a long period. Achievement of symmetry and regularity on vocal fold vibrations suggested the property changes had happened in the vocal folds. Consequently, the score of VHI-10 had improved, indicating high patient satisfaction with this treatment. Conclusion b FGF injections could be a reliable treatment option for diseases that deteriorate the property of vocal fold.
- Subjects :
- Male
medicine.medical_specialty
Fold (higher-order function)
Basic fibroblast growth factor
Urology
Vocal Cords
Injections, Intralesional
Stroboscope
Cicatrix
Young Adult
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
otorhinolaryngologic diseases
medicine
Long term outcomes
Humans
In patient
Stroboscopy
030223 otorhinolaryngology
Aged
Aged, 80 and over
Voice Disorders
business.industry
General Medicine
Middle Aged
Sulcus
Fibrosis
medicine.anatomical_structure
Vocal Cord Dysfunction
Otorhinolaryngology
chemistry
030220 oncology & carcinogenesis
Vocal folds
Female
Fibroblast Growth Factor 2
Surgery
Voice handicap
Atrophy
business
Subjects
Details
- ISSN :
- 03858146
- Volume :
- 48
- Database :
- OpenAIRE
- Journal :
- Auris Nasus Larynx
- Accession number :
- edsair.doi.dedup.....3002940b4d69c6a5d894415787c2a698