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Structure-based design and synthesis of pyrrole derivatives as MEK inhibitors
- Source :
- Bioorganic & Medicinal Chemistry Letters. 20:4156-4158
- Publication Year :
- 2010
- Publisher :
- Elsevier BV, 2010.
-
Abstract
- A novel series of pyrrole inhibitors of MEK kinase has been developed using structure-based drug design. Optimization of the series led to the identification of potent inhibitors with good pharmaceutical properties.
- Subjects :
- Models, Molecular
Molecular model
medicine.drug_class
Stereochemistry
Clinical Biochemistry
Pharmaceutical Science
Carboxamide
Mitogen-activated protein kinase kinase
Crystallography, X-Ray
Biochemistry
Chemical synthesis
chemistry.chemical_compound
Drug Discovery
medicine
Animals
Pyrroles
Protein Kinase Inhibitors
Molecular Biology
Pyrrole
chemistry.chemical_classification
Molecular Structure
biology
Kinase
Organic Chemistry
MAP Kinase Kinase Kinases
Rats
Enzyme
chemistry
Enzyme inhibitor
Drug Design
biology.protein
Molecular Medicine
Subjects
Details
- ISSN :
- 0960894X
- Volume :
- 20
- Database :
- OpenAIRE
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Accession number :
- edsair.doi.dedup.....2ffe4825c4752be8b34bd38a4133dc92
- Full Text :
- https://doi.org/10.1016/j.bmcl.2010.05.058