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Functional Role of Mitochondria in Arrhythmogenesis
- Source :
- Advances in Experimental Medicine and Biology ISBN: 9783319553290
- Publication Year :
- 2017
- Publisher :
- Springer International Publishing, 2017.
-
Abstract
- Growing evidence indicate that mitochondria play a functional role in arrhythmogenesis. We report here the molecular mechanisms underlying the action of these highly dynamic organelles in the regulation of cell metabolism, action potential and, overall, heart excitability. In particular, we examine the role of cardiac mitochondria in linking metabolism and cell excitability. The importance of the main mitochondrial channels is evaluated as well, including the recently identified calcium uniporter. Promises and pitfalls of potential therapeutic strategies targeting mitochondrial pathways are also assessed.
- Subjects :
- Genetics and Molecular Biology (all)
0301 basic medicine
Programmed cell death
Cell
Action Potentials
Arrhythmias
030204 cardiovascular system & hematology
Mitochondrion
Biology
Membrane Potential
Biochemistry
Article
Mitochondria, Heart
03 medical and health sciences
chemistry.chemical_compound
Adenosine Triphosphate
0302 clinical medicine
Animals
Anti-Arrhythmia Agents
Arrhythmias, Cardiac
Cell Death
Humans
Membrane Potential, Mitochondrial
Myocytes, Cardiac
Oxidative Stress
Reactive Oxygen Species
Signal Transduction
Energy Metabolism
Heart Rate
Medicine (all)
Biochemistry, Genetics and Molecular Biology (all)
Organelle
medicine
Myocytes
Heart
Mitochondrial
Mitochondria
030104 developmental biology
medicine.anatomical_structure
Cell metabolism
chemistry
Signal transduction
Cardiac
Adenosine triphosphate
Neuroscience
Subjects
Details
- ISBN :
- 978-3-319-55329-0
- ISBNs :
- 9783319553290
- Database :
- OpenAIRE
- Journal :
- Advances in Experimental Medicine and Biology ISBN: 9783319553290
- Accession number :
- edsair.doi.dedup.....2ff80dc853f3bb8a7fde454570d421f9