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The impact of Clostridium difficile infection on resource use and costs in hospitals in Spain and Italy: a matched cohort study

The impact of Clostridium difficile infection on resource use and costs in hospitals in Spain and Italy: a matched cohort study

Authors :
W.M. Hart
A. Asensio
Maureen Watt
Ricardo Scotto
Santiago Grau
Nicola Petrosillo
Jameel Nazir
Beatriz Isidoro
Stefano Di Bella
Andrea Lo Vecchio
Asensio, A
Di Bella, S
Lo Vecchio, A
Grau, S
Hart, Wm
Isidoro
Scotto, R
Petrosillo, N
Watt, M
Nazir, J
Isidoro, B
Source :
International Journal of Infectious Diseases, Vol 36, Iss C, Pp 31-38 (2015)
Publication Year :
2014

Abstract

Summary Objective To assess the impact of Clostridium difficile infection (CDI) on hospital resources and costs in Spain and Italy. Methods CDI data were collected from institutions in Spain and Italy. Each patient was matched with two randomly selected uninfected controls in the same institution. Patient outcomes were assessed for the first and second episodes of CDI and for patients aged ≤65 and >65 years. The impact of CDI on hospital length of stay (LOS) was used to calculate CDI-attributable costs. A multivariate analysis using duration of stay as the continuous outcome variable assessed the independent effect of CDI on hospital costs and LOS. Results LOS attributable to CDI ranged from 7.6–19.0 days in adults and was 5.0 days in children; the increases were greater in adults in Italy than in Spain. Attributable costs per adult patient ranged from €4396 in Madrid to €14 023 in Rome, with the majority of the cost being due to hospitalization. For children, the total attributable cost was €3545/patient. Conclusions These data show that the burden of CDI is considerable in Spain and Italy. Treatments that can reduce LOS, disease severity, and recurrence rates, as well as effective infection control measures to prevent transmission, have the potential to reduce the burden of CDI.

Details

ISSN :
18783511
Volume :
36
Database :
OpenAIRE
Journal :
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
Accession number :
edsair.doi.dedup.....2ff8039aa99d5b81ffbd600dc86042a8