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Temperature sensation in Parkinson's disease measured by quantitative sensory testing: a single-center, case-control study
- Source :
- The International journal of neuroscience.
- Publication Year :
- 2021
-
Abstract
- Background The pathophysiology of abnormal temperature sensation in Parkinson's disease (PD) remains unclear. Abnormal thermal detection does not seem to depend on the dopaminergic deficit, suggesting that other systems play a role in these changes, probably both central and peripheral. Methods We measured thermal detection thresholds (TDT) using quantitative sensory testing (QST) in 28 patients with PD and compared them with 15 healthy controls. Results Of 28 patients, 21% had increased TDT according to the normative data. TDT were higher on the dominant side. No correlation between TDT and disease duration, severity of motor impairment, and dopaminergic therapy was observed. 50% of the patients had difficulty differentiating between warm and cold stimuli, as TDT were within the normal range in most of these patients. Conclusions 21% of the patients in our study had increased TDT according to the normative data. Abnormal thermal detection was more pronounced on the dominant side. Abnormal differentiation between the thermal stimuli suggest impaired central processing of thermal information.
- Subjects :
- endocrine system
medicine.medical_specialty
Parkinson's disease
business.industry
General Neuroscience
Quantitative sensory testing
Dopaminergic
Case-control study
General Medicine
Disease
Audiology
medicine.disease
Single Center
Pathophysiology
Peripheral
stomatognathic diseases
medicine
business
Subjects
Details
- ISSN :
- 15635279
- Database :
- OpenAIRE
- Journal :
- The International journal of neuroscience
- Accession number :
- edsair.doi.dedup.....2ff7df95a603d8c31f2842c6e3064ffc