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Monitoring of magnetic targeting to tumor vasculature through MRI and biodistribution
- Source :
- Nanomedicine (London, England). 5(8)
- Publication Year :
- 2010
-
Abstract
- Aims: The development of noninvasive imaging techniques for the assessment of cancer treatment is rapidly becoming highly important. The aim of the present study is to show that magnetic cationic liposomes (MCLs), incorporating superparamagnetic iron oxide nanoparticles (SPIONs), are a versatile theranostic nanoplatform for enhanced drug delivery and monitoring of cancer treatment. Materials & methods: MCLs (with incorporated high SPION cargo) were administered to a severe combined immunodeficiency mouse with metastatic (B16-F10) melanoma grown in the right flank. Pre- and post-injection magnetic resonance (MR) images were used to assess response to magnetic targeting effects. Biodistribution studies were conducted by 111In-labeled MCLs and the amount of radioactivity recovered was used to confirm the effect of targeting for intratumoral administrations. Results: We have shown that tumor signal intensities in T2-weighted MR images decreased by an average of 20 ± 5% and T2* relaxation times decreased by 14 ± 7 ms 24 h after intravenous administration of our MCL formulation. This compares to an average decrease in tumor signal intensity of 57 ± 12% and a T2* relaxation time decrease of 27 ± 8 ms after the same time period with the aid of magnetic guidance. Conclusion: MR and biodistribution analysis clearly show the efficacy of MCLs as MRI contrast agents, prove the use of magnetic guidance, and demonstrate the potential of MCLs as agents for imaging, guidance and therapeutic delivery.
- Subjects :
- Biodistribution
Biomedical Engineering
Medicine (miscellaneous)
Contrast Media
Bioengineering
Mice, SCID
Development
Ferric Compounds
Fatty Acids, Monounsaturated
Magnetics
Mice
Neoplasms
Medicine
Animals
Humans
General Materials Science
Cationic liposome
Tissue Distribution
Neoplasm Metastasis
Melanoma
Fluorescent Dyes
Severe combined immunodeficiency
Liposome
Drug Carriers
medicine.diagnostic_test
business.industry
Magnetic resonance imaging
medicine.disease
Magnetic Resonance Imaging
Quaternary Ammonium Compounds
Kinetics
Drug delivery
Injections, Intravenous
Liposomes
Nanoparticles
business
Drug carrier
Nuclear medicine
Subjects
Details
- ISSN :
- 17486963
- Volume :
- 5
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- Nanomedicine (London, England)
- Accession number :
- edsair.doi.dedup.....2ff4872d52b9ff2dc02f8022d254d74c