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Functional magnetic resonance imaging of the primary somatosensory cortex in piglets
- Source :
- Journal of Neurosurgery: Pediatrics. 104:259-264
- Publication Year :
- 2006
- Publisher :
- Journal of Neurosurgery Publishing Group (JNSPG), 2006.
-
Abstract
- Object The piglet is an excellent model for the developing human brain, and has been used increasingly in various centers for studies of traumatic brain injury and other insults. Unlike rodent or primate models, however, there are few behavioral scales for the piglet, and the available ones are used to test general responsiveness rather than specific functional outcome. The differing behavioral repertoires of animals of different ages provide an additional challenge when age-dependent injury responses are compared. To overcome these experimental limitations of piglets in brain injury research, the authors developed a functional magnetic resonance (fMR) imaging paradigm that can be used to track recovery in the somatosensory cortex over time in anesthetized animals of different ages. Methods Fifteen fMR imaging studies in eight piglets were performed before and after scaled cortical impact injury to the primary somatosensory cortex subserving snout sensation. Specific anesthetic and imaging protocols enabled visualization of cortical activation, and comparison with somatosensory evoked potentials obtained before and after injury was obtained. A piglet brain template for group-level analysis of these data was constructed, similar to the fMR imaging techniques used in humans, to allow for group comparisons and longitudinal change analysis over time. Conclusions Loss of function in a specifically traumatized cortical region and its subsequent recovery over time can now be demonstrated visually by fMR imaging in the piglet. Besides its value in understanding intrinsic recovery mechanisms and plasticity at different ages, this functional outcome measure will enable the use of the piglet model in treatment trials specifically designed for the immature brain.
- Subjects :
- Swine
Traumatic brain injury
Somatosensory system
Evoked Potentials, Somatosensory
Head Injuries, Closed
Sensation
Image Processing, Computer-Assisted
Animals
Humans
Medicine
Child
Dominance, Cerebral
Brain Mapping
medicine.diagnostic_test
Echo-Planar Imaging
business.industry
Age Factors
Magnetic resonance imaging
Recovery of Function
Somatosensory Cortex
General Medicine
Human brain
Image Enhancement
medicine.disease
Magnetic Resonance Imaging
Functional imaging
Disease Models, Animal
medicine.anatomical_structure
Somatosensory evoked potential
business
Functional magnetic resonance imaging
Neuroscience
Subjects
Details
- ISSN :
- 19330707
- Volume :
- 104
- Database :
- OpenAIRE
- Journal :
- Journal of Neurosurgery: Pediatrics
- Accession number :
- edsair.doi.dedup.....2ff207d77c0a77cb03e7406670263954