Back to Search
Start Over
No evidence for an association between the Glu298Asp polymorphism of the NOS3 gene and Alzheimer's disease
- Source :
- Journal of Neural Transmission. 107:1081-1084
- Publication Year :
- 2000
- Publisher :
- Springer Science and Business Media LLC, 2000.
-
Abstract
- Recently a significant association of a missense mutation (Glu298Asp) of the endothelial nitric oxide synthase (NOS3) gene with late-onset Alzheimer's disease (LOAD) was reported. We tried to replicate this finding in a Japanese sample of 121 patients with LOAD, 51 with early-onset AD (EOAD), and 165 medical controls. However, the genotype and allelic distributions for the Glu298Asp polymorphism were similar for these three groups, suggesting that the Glu298Asp polymorphism of the NOS3 gene has no relevance to the development of AD in Japanese.
- Subjects :
- Genotype
Nitric Oxide Synthase Type III
Glutamic Acid
Disease
Biology
Polymorphism, Single Nucleotide
Degenerative disease
Gene Frequency
Japan
Alzheimer Disease
Polymorphism (computer science)
medicine
Humans
Missense mutation
Allele
Child
Gene
Biological Psychiatry
Aged
Genetics
Aspartic Acid
Middle Aged
medicine.disease
Psychiatry and Mental health
Neurology
Female
Neurology (clinical)
Nitric Oxide Synthase
Alzheimer's disease
Subjects
Details
- ISSN :
- 14351463 and 03009564
- Volume :
- 107
- Database :
- OpenAIRE
- Journal :
- Journal of Neural Transmission
- Accession number :
- edsair.doi.dedup.....2feccf18574bc6aa2b834dd4a4925f4e