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Infection, antibiotic exposure and development of atopic dermatitis: A nationwide case-control study
- Source :
- The Journal of dermatologyReferences. 47(7)
- Publication Year :
- 2019
-
Abstract
- Previous studies suggest an association between atopic dermatitis (AD) and exposure to microorganisms and antibiotics. However, these studies have limitations, and the sole influence on the development of AD was elusive. We performed a nationwide population-based case-control study in a Korean population to investigate the association between AD and early-life infection or antibiotic exposure. A total of 244 805 children with AD from the 2 283 601 children born between January 2010 and December 2014 and an equal number of sex- and age-matched healthy children were enrolled. A conditional logistic regression analysis showed that the episode of infection and antibiotic exposure were associated with an increased risk of AD (odds ratio [OR], 1.60; 95% confidence interval [CI], 1.58-1.63 for infection; and OR, 1.11; 95% CI, 1.09-1.13 for antibiotic exposure). A dose-dependent relationship was observed between risk for AD, the number of infection episodes and antibiotic cycles and the duration of antibiotic exposure. On further analysis using a conditional logistic model, the risk of AD was less when the antibiotics were used during the infection episode than that without the use of antibiotics, especially if the duration of the infection was short. Although our study could not consider the effect of cause or severity of infection, class of antibiotics and genetic or environmental factors of enrolled subjects, our results suggested that infection and antibiotic exposure were associated with an increased risk of AD. In addition, the results also implied that the use of antibiotics during an infection episode can decrease the risk of AD induced by the infection and that appropriate management of infections can minimize the risk of AD induced by infection or antibiotics.
- Subjects :
- medicine.medical_specialty
medicine.drug_class
Antibiotics
Population
Eczema
Dermatology
Logistic regression
Dermatitis, Atopic
030207 dermatology & venereal diseases
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
Odds Ratio
Humans
education
Child
education.field_of_study
business.industry
Antibiotic exposure
Case-control study
General Medicine
Atopic dermatitis
Odds ratio
medicine.disease
Confidence interval
Anti-Bacterial Agents
030220 oncology & carcinogenesis
Case-Control Studies
business
Subjects
Details
- ISSN :
- 13468138
- Volume :
- 47
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- The Journal of dermatologyReferences
- Accession number :
- edsair.doi.dedup.....2feb53ecf89d8c9d2c00a1d6ebcc71f8