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Polymorphism at the apical membrane antigen 1 gene (AMA1) of the malaria parasite Plasmodium falciparum in a Vietnamese population
- Source :
- Biochemical genetics. 47(5-6)
- Publication Year :
- 2008
-
Abstract
- The patterns of molecular evolution of the most diverse region of the apical membrane antigen 1 (AMA1) gene in Plasmodium falciparum from a Vietnamese subpopulation (Bao Loc) were investigated. Within the Bao Loc population, the sequenced gene region showed relatively high allelic and nucleotide diversity (0.985 and 0.02694, respectively). Further, the level of population recombination was substantial, resulting in a significant decay of linkage disequilibrium along the gene region. The results suggest that AMA1 is a useful genetic marker for studying the relationships between adaptation of parasite populations (to the human host immune system) and malaria epidemiology.
- Subjects :
- Linkage disequilibrium
Genotype
Population
Plasmodium falciparum
Protozoan Proteins
Antigens, Protozoan
Biochemistry
Linkage Disequilibrium
Nucleotide diversity
Gene Frequency
Molecular evolution
parasitic diseases
Genetics
Animals
Humans
Apical membrane antigen 1
Malaria, Falciparum
education
Molecular Biology
Gene
Ecology, Evolution, Behavior and Systematics
education.field_of_study
Polymorphism, Genetic
biology
Base Sequence
Genetic Variation
Membrane Proteins
General Medicine
Sequence Analysis, DNA
DNA, Protozoan
biology.organism_classification
Haplotypes
Vietnam
Genetic marker
Subjects
Details
- ISSN :
- 15734927
- Volume :
- 47
- Issue :
- 5-6
- Database :
- OpenAIRE
- Journal :
- Biochemical genetics
- Accession number :
- edsair.doi.dedup.....2fe1c4412436c9ae2597c925fb0afe0e