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Imaging features of thalassemia
- Source :
- European Radiology. 9:1804-1809
- Publication Year :
- 1999
- Publisher :
- Springer Science and Business Media LLC, 1999.
-
Abstract
- Thalassemia is a kind of chronic, inherited, microcytic anemia characterized by defective hemoglobin synthesis and ineffective erythropoiesis. In all thalassemias clinical features that result from anemia, transfusional, and absorptive iron overload are similar but vary in severity. The radiographic features of beta-thalassemia are due in large part to marrow hyperplasia. Markedly expanded marrow space lead to various skeletal manifestations including spine, skull, facial bones, and ribs. Extramedullary hematopoiesis (ExmH), hemosiderosis, and cholelithiasis are among the non-skeletal manifestations of thalassemia. The skeletal X-ray findings show characteristics of chronic overactivity of the marrow. In this article both skeletal and non-skeletal manifestations of thalassemia are discussed with an overview of X-ray findings, including MRI and CT findings.
- Subjects :
- Male
Ineffective erythropoiesis
congenital, hereditary, and neonatal diseases and abnormalities
medicine.medical_specialty
Pathology
Anemia
Microcytic anemia
Thalassemia
Hemosiderosis
Kidney
medicine.disease_cause
Bone and Bones
Diagnosis, Differential
Bone Marrow
hemic and lymphatic diseases
Adrenal Glands
medicine
Humans
Radiology, Nuclear Medicine and imaging
Breast
medicine.diagnostic_test
business.industry
Magnetic resonance imaging
General Medicine
medicine.disease
Magnetic Resonance Imaging
Extramedullary hematopoiesis
Skull
medicine.anatomical_structure
Liver
Female
Radiology
Tomography, X-Ray Computed
business
Spleen
Subjects
Details
- ISSN :
- 14321084 and 09387994
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- European Radiology
- Accession number :
- edsair.doi.dedup.....2fe11e5405b1cf46fe88a1bb08915e27