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Molecular Profiling of Keratinocyte Skin Tumors Links Staphylococcus aureus Overabundance and Increased Human β-Defensin-2 Expression to Growth Promotion of Squamous Cell Carcinoma
- Source :
- Cancers, Volume 12, Issue 3, Cancers, Vol 12, Iss 3, p 541 (2020)
- Publication Year :
- 2020
- Publisher :
- MDPI AG, 2020.
-
Abstract
- The skin microbiota plays a prominent role in health and disease<br />however, its contribution to skin tumorigenesis is not well understood. We comparatively assessed the microbial community compositions from excision specimens of the main human non-melanoma skin cancers, actinic keratosis (AK), squamous cell carcinoma (SCC) and basal cell carcinoma (BCC). Keratinocyte skin tumors are characterized by significantly different microbial community compositions, wherein AK and SCC are more similar to each other than to BCC. Notably, in SCC, which represents the advanced tumor entity and frequently develops from AK, overabundance of Staphylococcus aureus, a known skin pathogen, was noted. Moreover, S. aureus overabundance was significantly associated with increased human &beta<br />defensin-2 (hBD-2) expression in SCC. By challenging human SCC cell lines with S. aureus, a specific induction of hBD-2 expression and increased tumor cell growth was seen. Increased proliferation was also induced by directly challenging SCC cells with hBD-2. Together, our data indicate that a changed microbial community composition in SCC, specified by S. aureus overabundance, might promote tumor cell growth via modulation of hBD-2 expression.
- Subjects :
- squamous cell carcinoma
0301 basic medicine
Staphylococcus aureus
Cancer Research
skin microbiota
Antimicrobial peptides
Medizin
Biology
medicine.disease_cause
lcsh:RC254-282
digestive system
Article
antimicrobial peptides
03 medical and health sciences
fluids and secretions
0302 clinical medicine
basal cell carcinoma
actinic keratosis
medicine
Basal cell carcinoma
neoplasms
Pathogen
staphylococcus aureus
integumentary system
human β-defensin
Actinic keratosis
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
medicine.disease
stomatognathic diseases
030104 developmental biology
medicine.anatomical_structure
Oncology
Cell culture
030220 oncology & carcinogenesis
Cancer research
Carcinogenesis
Keratinocyte
Subjects
Details
- ISSN :
- 20726694
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Cancers
- Accession number :
- edsair.doi.dedup.....2fd52c312f22d979e325137110fffc80