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(+)- and (−)-liriodenol, a pair of novel enantiomeric lignans from Liriodendron hybrid
- Source :
- Bioorganic & Medicinal Chemistry Letters. 25:1976-1978
- Publication Year :
- 2015
- Publisher :
- Elsevier BV, 2015.
-
Abstract
- (+)- and (-)-liriodenol, a pair of unprecedented enantiomeric lignans bearing a 1,1-disubstituted olefinic group, were isolated from the barks of Liriodendron hybrid. The structure and relative configurations were determined by comprehensive analysis of MS and NMR spectroscopy. The cytotoxicity of these three lignans ((±)-, (+)-, and (-)-liriodenol) was evaluated in vitro against four selected human tumor cell lines, where (+)-liriodenol showed more significant cytotoxic effects than the (±)- and (-)-liriodenol enantiomers.
- Subjects :
- Liriodendron
Cell Survival
Stereochemistry
Clinical Biochemistry
Pharmaceutical Science
Stereoisomerism
Biochemistry
Lignans
Colorimetry (chemical method)
Structure-Activity Relationship
Cell Line, Tumor
Drug Discovery
Humans
Molecule
Structure–activity relationship
Cytotoxicity
Molecular Biology
Cell Proliferation
Dose-Response Relationship, Drug
Molecular Structure
Chemistry
Organic Chemistry
Nuclear magnetic resonance spectroscopy
Molecular Medicine
Colorimetry
Enantiomer
Subjects
Details
- ISSN :
- 0960894X
- Volume :
- 25
- Database :
- OpenAIRE
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Accession number :
- edsair.doi.dedup.....2fcf0f0a284d6781101925f7d00fe0f2