Back to Search
Start Over
Influence of surgical decompression on the expression of inflammatory and tissue repair biomarkers in periapical cysts
- Source :
- Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. 124:561-567
- Publication Year :
- 2017
- Publisher :
- Elsevier BV, 2017.
-
Abstract
- Objective The biologic effects of surgical decompression on the epithelium and connective tissues of periapical cysts are not fully understood. The aim of this study was to evaluate the expression of tissue repair and inflammatory biomarkers in periapical cysts before and after surgical decompression. Study design Nine specimens of periapical cysts treated with decompression before undergoing complete enucleation were immunohistochemically analyzed to investigate the expression of interleukin-1β, tumor necrosis factor-α, transforming growth factor-β1, matrix metalloproteinase-9, Ki-67, and epidermal growth factor receptor. Expression of the biomarkers was classified as positive, focal, or negative. Ki-67 immunoexpression was calculated as a cell proliferation index. The expression of the biomarkers was compared in the specimens from decompression and from the final surgical procedure. Results Computed tomography demonstrated that volume was reduced in all cysts after decompression. There were no differences in the immunoexpression of the proinflammatory and tissue repair biomarkers when comparing the specimens obtained before and after the decompression. Conclusions Surgical decompression was efficient in reducing the volume of periapical cysts before complete enucleation. When comparing the specimens obtained from surgical decompression and from complete surgical removal, the immunohistochemical analysis did not show a decrease in proinflammatory biomarkers; neither did it show an increase in tissue repair biomarkers.
- Subjects :
- Adult
Male
musculoskeletal diseases
Pathology
medicine.medical_specialty
Adolescent
Decompression
Interleukin-1beta
Enucleation
Pathology and Forensic Medicine
Proinflammatory cytokine
Transforming Growth Factor beta1
03 medical and health sciences
Surgical decompression
0302 clinical medicine
medicine
Humans
Radiology, Nuclear Medicine and imaging
Dentistry (miscellaneous)
Epidermal growth factor receptor
Aged
Cell Proliferation
Radicular Cyst
biology
Tumor Necrosis Factor-alpha
business.industry
030206 dentistry
Middle Aged
Decompression, Surgical
Immunohistochemistry
Epithelium
ErbB Receptors
Ki-67 Antigen
medicine.anatomical_structure
Matrix Metalloproteinase 9
030220 oncology & carcinogenesis
biology.protein
Female
Surgery
Oral Surgery
Tomography, X-Ray Computed
business
Biomarkers
Subjects
Details
- ISSN :
- 22124403
- Volume :
- 124
- Database :
- OpenAIRE
- Journal :
- Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
- Accession number :
- edsair.doi.dedup.....2fcea7682cf1d3a2cacb43534b904221