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Plasma sex hormone-binding globulin predicts neurodegeneration and clinical progression in prodromal Alzheimer's disease
- Source :
- Aging (Albany NY)
- Publication Year :
- 2020
- Publisher :
- Impact Journals, LLC, 2020.
-
Abstract
- It was unclear whether sex hormone-binding globulin (SHBG) was a circulating biomarker of Alzheimer’s disease (AD). We tested the cross-sectional relationships between plasma SHBG and cerebrospinal fluid (CSF) AD biomarkers in 707 non-demented adults. Next, the influences of plasma SHBG on dynamic changes of CSF Aβ42, hippocampus volume, brain metabolism, and cognition were explored in 448 non-demented adults from the Alzheimer’s disease Neuroimaging Initiative (ADNI). Finally, the predictive and diagnostic values of plasma SHBG in AD were explored. A positive correlation was found between SHBG levels in plasma and CSF. Individuals with higher plasma SHBG levels had lower CSF Aβ42 (p < 0.005), after adjusting for age, gender, education, APOE4 allele, and cognitive scores. Though no significant difference of plasma SHBG was observed between mild AD dementia and healthy normal, plasma SHBG could contribute to accelerated rates of CSF Aβ42 decrease (p < 0.0005), decline in brain metabolism (p < 0.05), and hippocampus atrophy (p < 0.01), cognitive decline (p < 0.01), as well as higher risk of AD dementia (p < 0.05). These findings indicated plasma SHBG could be a prodromal biomarker to predict disease progression in AD.
- Subjects :
- Adult
Male
Aging
medicine.medical_specialty
Prodromal Symptoms
Neuropsychological Tests
Hippocampus
cerebrospinal fluid
Sex hormone-binding globulin
Cerebrospinal fluid
Atrophy
Alzheimer Disease
Predictive Value of Tests
Sex Hormone-Binding Globulin
Internal medicine
polycyclic compounds
medicine
Humans
Dementia
Hippocampus (mythology)
Cognitive Dysfunction
Cognitive decline
plasma
reproductive and urinary physiology
Aged
Aged, 80 and over
Brain Chemistry
Amyloid beta-Peptides
biology
business.industry
Neurodegeneration
Neurodegenerative Diseases
Cell Biology
Middle Aged
Prognosis
medicine.disease
Peptide Fragments
Cross-Sectional Studies
Endocrinology
Disease Progression
biology.protein
biomarker
Biomarker (medicine)
Female
business
Alzheimer’s disease
Biomarkers
hormones, hormone substitutes, and hormone antagonists
Research Paper
Subjects
Details
- ISSN :
- 19454589
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Aging
- Accession number :
- edsair.doi.dedup.....2fcbbce9febdb8526c74db8ad85fd2a1